There may be a promising new treatment on the horizon for advanced breast cancer patients, according to developing research.

Researchers are studying the cancer-killing drug trastuzumab rezetecan for those with ERBB2-low metastatic breast cancer, whose tumors have low levels of HER2, a protein that can help cancer cells grow.

A phase 3 clinical trial called HORIZON-Breast06 sought to determine whether the drug works better than standard chemotherapy for patients with this cancer type.

SHIFT IN CANCER SCREENING GUIDANCE HAS EXPERTS CLASHING OVER NEW GUIDANCE

The researchers analyzed 551 female patients across 73 hospitals in China who were randomly assigned to receive either the drug intravenously every three weeks, or the physician’s choice of chemotherapy. The study period lasted from June 2023 to August 2025.

The drug significantly delayed cancer progression compared with chemotherapy, giving patients more than a year before their cancer began growing again.

The median time without tumor growth was 16.4 months compared to 6.8 months with chemo.

FDA APPROVES ONCE-DAILY PILL FOR DEADLY CANCER AFTER PATIENTS' SURVIVAL RATES NEARLY DOUBLE

Patients who received trastuzumab rezetecan were 73% less likely to have their cancer worsen or die during the study than patients who received chemotherapy.

The drug appeared to delay cancer progression in patients with both hormone receptor-positive and hormone receptor-negative breast cancer.

The results were published in JAMA.

Tumors shrank in 75.5% of patients who received the drug, compared with 41.2% of those who received chemotherapy.

At the 12-month mark, 90.6% of trastuzumab rezetecan patients were alive, compared to 81.4% of chemo patients.

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The authors concluded that trastuzumab rezetecan provided "significant progression-free survival benefit over physician’s choice of chemotherapy in patients with ERBB2-low advanced breast cancer."

Loren Rourke, a Texas-based breast surgical oncologist and author in Texas, called the results "incredibly encouraging."

"When you're talking about women living with advanced breast cancer, those months matter," Rourke, who was not involved in the study, told Fox News Digital. "They represent more time when the cancer is being held in check and potentially more opportunities to enjoy life without the disease getting worse."

What makes these findings especially exciting, according to the oncologist, is that the treatment showed benefits across different types of breast cancer.

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"It's another important step forward, and it gives us genuine reason to be hopeful," she said. "A treatment that can keep cancer from progressing for a longer period has the potential to make an enormous difference in a patient's life."

While the drug may cause fewer serious lung problems than similar treatments, it was linked to other side effects, including anemia and other blood-related problems.

Serious side effects occurred in more than 84% of patients who received the new drug, compared with nearly 68% of those who received chemotherapy.

Rourke emphasized the importance of considering the side effects, "because more time without cancer progression doesn't automatically mean better quality of life."

"We need to better understand the side effects, particularly the significant decreases in blood counts that can lead to fatigue, anemia and increased risk of infection," she said.

The researchers acknowledged that toxicity occurred more frequently and often required dose modification, although they said these effects were "generally manageable."

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The experts agreed that more research is needed.

"As exciting as these findings are, there are still important questions we need to answer," Rourke told Fox News Digital. "We know this treatment delayed cancer progression, but we don't yet know whether it will help patients live longer. That's an important distinction."

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"It's important to celebrate meaningful progress while making sure we're asking the right questions about what comes next."

What's a spending habit rich people have that is totally worth it?

As the loyal readers know, I am a big fan of Reddit. When it comes to places on the internet where you can find yourself going down deep rabbit holes, there's probably no place that beats Reddit.

You simply never know what you're going to find. There are plenty of crazy stories, history lessons and really cool military content on Reddit.

REDDIT THREAD ON LIFE CHEAT CODES GOES VIRAL WITH ADVICE ON FITNESS, SLEEP AND COMPOUND INTEREST

There's also plenty of debates and discussions, and that's what leads us here today.

Convenience habits of rich people go viral on Reddit

I was scrolling the r/askreddit subreddit early Thursday morning when I stumbled across and interesting thread title that caught my attention:

AMERICANS SAY THEY'RE BROKE. SO WHY CAN'T THEY STOP SPENDING SO MUCH?

What's a 'rich people' thing you tried once and immediately understood why they do it?

As someone interested in money (aren't we all, after all?), it was an instant click from me. The results didn't disappoint at all.

Let's check out some of the replies before breaking it down:

• I drive a Lexus. Oh, wait, it's 20 years old. Regardless I feel like a princess behind the wheel.
• Ordering groceries that arrive pre chopped, pre washed, and neatly portioned. I laughed at the price tag once, tried it during a burnout week, and instantly understood. It’s not buying food it’s buying back two hours of your Sunday so you don't spend it crying over a cutting board.
• Don't ever fly business class on a long haul flight unless you can afford to do it regularly. Once you know... economy sucks so much harder.
• Custom made clothes. Had a dress made for a special event. Fit me like a glove, looked perfect on me, and I felt like a queen. Would get my whole wardrobe custom made if I had them money.
• Flew private. Our organization has a small place and the pilots have to have a certain number of flight hours per month so we asked to fly to a regional meeting. I parked, walked in, waited for the plane to land, got a short safety briefing, then walked 30 feet to the plane and boarded. No one even checked my ID. I 100% understand why people do this. It was so so nice not to have to deal with airport parking, TSA, or loading a commercial plane (where I always fly cheap af).
• Hiring movers. Not sure if this counts, but I hired a moving company to move my stuff for the first time. Was like half a garage and a rooms worth of stuff. $500 later and it’s just where you need it to be. Parents divorced when I was young. They seemed to lease a new house every year, so lots of moving. Finally realized it doesn’t have to be a terrible process and I can just have someone else do it all and it’s so worth it.
• Flying first class. Apparently the difference between hating air travel and enjoying it is about six inches of legroom and a glass of champagne.
• What I'm getting from this thread is that flying is miserable if you're not rich
• I bought a bespoke suit. Made me look like James Bond. And ruined off the rack suits for me. You essentially don't want to wear anything else.
• Anything above economy for long haul flights. I just did premium economy and the difference was enough to nearly spoil me. I can't imagine how it feels in business and first.
• I bought vip packages to a music festival. Was like $10 a person extra with access to private lounge and things. I only did it for the great access bathrooms. That alone was easily worth it to me.
• Cleaning lady. Never did it myself, but I dated a woman with a cleaning lady. Picked her up at a messy home, had a nice time out, came back to a spotless home. Unbelievable experience. If I ever have money, cleaning lady.
• Went to the warmer states during the winter months.
• Taking a $40 uber right to my destination instead of having to take a bus to a train to a bus and walking several blocks.
• Eating at a really nice restaurant. I am talking about a Michelin star restaurant. I went to one on a work trip once.
• Hiring a moving company
• Having someone clean your house for you. I finally understand why rich people pay for convenience.

Now, as the readers also know, I'm a working class guy from rural Wisconsin. You grow up fast when you grow up in those harsh winters. Life doesn't have many luxuries and you learn to get by with what you have.

Having said that, I have tasted the high-life once or twice, and without question flying first class is the obvious answer to this viral Reddit question.

Are there much more expensive things rich people have access to? Sure, but flying first class is attainable for most people if they want it to be, and it makes the flying experience significantly better.

Not a little bit better.

Much better.

Taking a seat on a first class flight – I've always found Delta to be the best – and being immediately greeted with a snack and drink instantly makes the hellish airport experience better.

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It's almost impossible to go back once you've been in first class.

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What's your splurge item that wealthy people enjoy? Let me know at David.Hookstead@outkick.com.

Amid a growing trend of parent-child estrangement, experts say recognizing the early warning signs may help families address problems before they escalate into a no-contact situation.

Nearly four in 10 Americans are currently estranged from at least one close family member, according to a 2025 YouGov poll of 4,395 U.S. adults. That includes 24% who reported estrangement from a sibling, 16% from a parent and 10% from a child.

While estrangement can sometimes seem sudden, experts say subtle changes may signal that a family relationship is beginning to unravel.

CUT OFF BY YOUR ADULT CHILD? PSYCHOLOGY RESEARCHER REVEALS WHAT PARENTS SHOULD DO NEXT

The quiet signs

Mary McLaughlin, a licensed couples and family therapist in Vienna, Virginia, said early signs may include an adult child becoming less willing to share details of their life directly with a parent.

"You might find out about the trip, the new relationship or a promotion at work at the same time everyone else does," she told Fox News Digital.

The parent may still be in contact with the adult child, McLaughlin said, but the child no longer chooses to share parts of their life directly.

ADULT CHILDREN CUTTING OFF PARENTS AS SOME BLAME THERAPY FOR FAMILY ESTRANGEMENTS

Other potential warning signs may include skipping family holidays, birthdays or weddings; leaving texts and calls unanswered; and reducing communication to brief or sporadic exchanges, according to the expert.

The distance may become so noticeable that siblings, grandparents or other relatives comment that they have not seen or heard from the adult child in a long time.

A child who once readily joined family photos but begins stepping out of them may also be signaling that they are starting to see themselves as separate from the family, McLaughlin said.

Blythe Landry, a Pennsylvania-based therapist and founder of Blythe Landry Coaching, said other early signs may include a child becoming involved with a new social group that encourages estrangement over difficult conversations, or "beginning to rewrite history in a way that seems more damaging than what might have happened."

The adult child may also become less willing to let a parent spend time with their grandchildren.

‘QUIET QUITTING’ IN MARRIAGE: THE SUBTLE SIGNS A SPOUSE HAS EMOTIONALLY CHECKED OUT

The most telling sign may be a noticeable shift in the tone of the relationship, Landry said.

"You know your child, and you know when the energy has shifted in a direction that seems dramatically harsher than in previous interactions."

The shift to independence

Laura Wellington, a Connecticut mother who has been estranged from her adult daughter since 2024, said it can be challenging to distinguish early signs of estrangement from typical moves toward independence.

"It’s confusing to the parent because, a lot of times, they look like the general signs of a teenager moving into the young-adult zone — just pulling away and going off and establishing their lives," she told Fox News Digital.

"That’s what I think confuses many parents, because they want to give them the space to start pulling away and showing signs of their own individuality and carving their path."

"They don’t want to fight every battle, because if they fight every battle, then communication breaks down. So they try to pick and choose."

Loss of respect

One warning sign, according to Wellington, is if the child has an "I know everything, you know nothing" mindset.

"What's happening in our society today is … a lot of ‘I know everything, you know nothing’ toward the parent," she said. "There's no respect for what the parents experience. There's no tolerance for them speaking up and saying, ‘No, this is not what you should be doing.’"

In some cases, the child may begin treating the parent as a subordinate, according to Wellington.

Some parents begin to notice a shift when their adult children start treating them with disrespect, pushing back on their opinions and positioning themselves as the authority in the relationship, she said.

"They become the authority; they flip it. Anytime you say something, you’ll see them bark at the parent and push back on the parent. They really have no respect for the parent."

Different worldviews

Wellington also pointed to major differences in political, religious or lifestyle beliefs as a possible source of growing distance between parents and adult children.

She suggested that some young people who become estranged are "more liberal in thinking," while acknowledging that the dynamic can also work in the opposite direction when a parent holds especially strong ideological views.

"There is extremism sometimes where the parent is extremely something, and then the child … goes the other way," she said.

Richard Blake, Ph.D., a Texas-based psychology researcher who focuses on anxiety and family estrangement, said an adult child’s unwillingness to consider differing views may signal trouble.

He suggested that personality may play a role, with more argumentative adult children who are less willing to consider differing views potentially more prone to family estrangement.

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Repeated cutoffs

Another possible warning sign, according to Blake, is if the adult child has begun cutting off other people. He said parents should take note if an adult child has repeatedly stopped speaking to relatives or openly boasts about ending relationships.

"Chances are, they're going to cut off someone else, and it may be the parent," he said. "If you haven’t been cut off yet, you may be in the firing line there."

Communication breakdown

Ongoing communication problems may be an early warning sign, Blake said, particularly when an adult child feels that a parent refuses to listen or acknowledge the child’s point of view.

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"They may say, 'My parents just don’t listen. I cannot get through to them. It’s like talking to a brick wall.'"

Parents who consistently dismiss their children’s concerns should not be surprised when conflict develops, he said.

"If you don’t listen to your child, then don’t be surprised if you have conflict with them."

Blake recommends listening actively, avoiding interruptions, repeating back what the other person has said and asking a simple follow-up question: "First, you say, 'Is there more?'"

No clear warning

While there may be some early signs, Blake emphasized that estrangement can sometimes appear suddenly, with no warning.

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"A lot of parents will say, ‘My child never told me the issue. We were best friends. And then I got a letter saying, never contact me ever again.’"

"That is a big problem. It's like people don't even know why they get cut off."

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Landry noted that recognizing possible warning signs should prompt honest self-reflection, not just concern about the other person’s behavior.

"If there is an imminent estrangement, dig deep," she advised. "Do you have a part? If so, is there a chance of rectifying it before it occurs?"