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The prescribing cascade: the error of treating side effects with more drugs

When an adverse effect is mistaken for a new disease, another drug is prescribed.

Marta Tello is a 23-year-old pharmacist who works in Algete, in the Madrid region of Spain. Six months ago, while completing her training with a primary care team in Seville, she encountered a clinical case that she says she will remember throughout the professional career she is just beginning: “This person was taking 18 different medications, something striking even for an 80-year-old with multiple underlying conditions. When we reviewed the case, we identified several prescribing cascades that needed to be reassessed,” she says.

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Marta Tello, at the González Pérez pharmacy where she works in Algete, Madrid.A family doctor reviews a patient’s medications with her at a health center in Barcelona.
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The best strategy against superbugs: Wait 48 hours before taking antibiotics, and only use them if symptoms worsen

Antibiotic packaging on a pharmacy shelf in Madrid.

The so-called “delayed prescribing” is an evidence-based strategy that remains underused despite concerns over the misuse of antibiotics and the rise of superbugs, which are responsible for an estimated 1.2 million deaths worldwide each year. Under this approach, a doctor prescribes treatment for a patient with a respiratory infection but advises them to monitor their symptoms and wait up to 72 hours before collecting the medication from the pharmacy and starting the course.

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