• Strauss Zelnick, the CEO of Take-Two Interactive, said he prefers working out to playing video games.
• He is a longevity buff, deep into fitness and anti-aging habits.
• In a candid conversation with Business Insider, he said skip the peptides, and try these 7 things instead.

Media mogul Strauss Zelnick spends his days hyper-focused on making the most creative, innovative, best video games in the world.

As the CEO and Chairman of video game-maker Take-Two Interactive, he's readying to release Grand Theft Auto 6 next month.

At home though, he doesn't play games. He prefers to spend his time working out and staying healthy for a long time.

At Business Insider's "The Long Play" event on Thursday, Zelnick said his formula for healthy aging is both simple and effective.

While he calls biohacker Bryan Johnson, the man behind the "Don't Die" movement, a friend, he said trying to live forever is a pretty silly strategy.

"There's almost no evidence that anything anyone is doing will increase your lifespan," he told Business Insider's Senior Leadership & Workplace Correspondent, Sarah Needleman. "How many of us really want to increase our lifespan from like 96 to 101? Look, that is not on my bucket list, thank you very much."

Instead, Zelnick, who wrote a book on "Becoming Ageless" in 2018, focuses on the same core behaviors for "taking care of yourself" that longevity experts around the world swear by for maintaining health and happiness for the long haul.

1: Do not smoke

"Smoking is the factor most highly correlated with a short, unhealthy, and frankly, unhappy life," Zelnick said. "Don't smoke."

2: Don't abuse alcohol and drugs

These lead to "a bad old age, or no old age," he said.

3: Get some exercise

Zelnick said: "You don't have to do what I do," with 6 a.m. wakeup calls for group training sessions, or twice-a-day workouts.

"I do what I do because I love it, it's my passion," he said. "If you walk 30 minutes a day, four or five days a week — just walk — you're like 80% of the way there."

4: Eat a "responsible" diet

Zelnick says he doesn't have an "insanely healthy diet," but he tries to maintain some balance. "I eat a lot of vegetables and salads and protein — I also like sweets, and I do eat carbs."

5: Sleep at least 7 hours a day

Zelnick says he treats this as a non-negotiable for his business.

"If you're getting less than six hours, you're making bad decisions," he said.

6: Have "some kind of emotional or spiritual life"

Longevity experts stress this is key for mental health, and establishing a sense of purpose in the world.

7: Find community

Zelnick said it's critical to get support from "people who love you."

8: Skip overhyped health hacks

Zelnick says don't waste your time with all the overhyped, unproven health hacks.

"All the other stuff, like, peptides? A: No," he said. "We have an FDA for a reason. Don't take something that is not double-blind tested."

And, he said, be careful with some of the internet's most famous longevity gurus. He name-checked controversial Harvard professor David Sinclair, who has made bold promises about the anti-aging effects of unproven supplements, including resveratrol, a plant polyphenol found in grapes and red wine, and NMN, which is a precursor to NAD, the vital coenzyme that's in every cell of our body.

"A medical doctor actually is a degree: M-D, an MD degree," Zelnick said. "Not a David Sinclair degree, he is not actually a doctor."

• I was diagnosed with ADHD at 38. I spent most of my life masking things I didn't know were ADHD.
• Instead of pretending I'm fine, I tell my sons when my brain is full and my battery is running low.
• I'm teaching them that everybody has different limits and it's important to know and respect them.

There are nights when I look at my two boys, 13 and 10, and announce, "My battery is at 1%."

They know what this means.

I get much quieter. The pile of clothes I told myself I was going to fold gets moved to the floor and becomes tomorrow's problem. Video game sounds that normally wouldn't bother me suddenly send my whole system into overdrive. If both kids are talking to me at once, I sometimes have to say, "I can't process what either one of you is saying right now."

Eventually, I can hit what feels like an actual wall. I go into a burnout shutdown where decision-making becomes almost impossible. My brain feels frozen. I know there are things I should be doing, but I can't organize them into a next step. If I'm overstimulated enough, I can barely formulate a cohesive thought.

Sometimes the only thing that helps is going into my room, closing the door, and sitting in complete silence.

I don't hide this from my kids. I let them see it on purpose.

I spent most of my life not knowing my brain worked differently

I was diagnosed with ADHD at 38. Until then, I genuinely didn't know other people's brains worked the way mine did. The best way I can describe my brain is that there are three musicals happening on three different stages at the same time. There are songs, conversations, ideas, and a constant stream of thoughts all competing for my attention.

From the outside, I looked highly functional. I was an A+ student. I worked hard. I got things done. I became an entrepreneur.

Internally, I was exhausted to the point that it sometimes felt like an existential level.

I remember hitting this same wall when I was around the same age as my sons. My parents didn't understand what was happening, and why would they? ADHD wasn't something anyone was considering for me. I wasn't physically hyperactive. All of the pinging was happening inside my head. So I learned to push through it and, eventually, to look calm while doing it.

In our family, we talk about our batteries

Our family therapist gave us an analogy that has become part of our language: Everybody is like a cell phone. Our batteries drain differently, and they recharge differently.

My older son is an introvert like me. We can love being around people and still need significant quiet afterward. For me, recharging means real quiet — a chunk of time when nobody is talking to me, asking me a question, or needing me to make a decision.

My younger son, who also has ADHD, is almost the opposite. I always say he's fueled by people. Talking to friends and being around other people can actually charge him. I love that distinction because even people whose brains are wired similarly don't necessarily need the same things.

There isn't one correct way to recharge.

I want my kids to know before they're 38

Being a single parent means I can't disappear into silence every time my battery gets low. Sometimes the video game is still playing. Somebody still needs something. Life keeps happening.

I've stopped believing that being a good mother means hiding the fact that I have limits. I'm not asking my children to take care of me. I'm letting them know me.

I want them to understand that people who love each other get to be human in front of one another. You can say, "I need quiet." You can say, "I need people." You can say, "My brain is too full right now." Limits aren't character flaws, and rest isn't something you earn only after you've completely depleted yourself.

For most of my life, I thought strength meant pushing through until nobody could tell I was struggling. I'm trying to teach my kids something different: learn what drains your battery. Learn what charges it. Tell the people you love what you need. And don't wait until you're at 1% to plug yourself back in.

• A new study explored the differences between tumors in younger and older colon cancer patients.
• Younger patients sometimes had more aggressive, treatment-resistant forms of colon cancer.
• Staying active, cutting down on processed foods, and getting screened are good ways to lower risk.

People under 50 aren't only at a higher risk of colon cancer today than they were a few decades ago. They're also developing a different, sometimes more aggressive form of it compared to older patients, scientists say.

A new study published in Nature Medicine analyzed 189 tumors from colorectal cancer patients aged 29 to over 90, including measurements of gene activity in more than 850,000 cancer cells.

The goal was to look at how tumors varied "across the entire spectrum of age," Dr. Ana Anderson, a co-senior author of the study who leads the cancer immunology program at the Gene Lay Institute at Brigham and Women's Hospital in Boston, told Business Insider. "Is it the same colon cancer but just happening in younger people, or is there something different about it?"

As a result, the study was able to map out gradual, subtle differences in colorectal cancer tumors correlated with age. While the researchers couldn't pinpoint exactly why tumors in younger people look different, Anderson said the study is an exciting starting point for further research.

"There's a lot of interest in lifestyle factors and environmental exposures as potential contributors; however, nothing specific has been pinned down," Anderson said. "What we did is take a rather simple but comprehensive approach just to try to understand the disease itself."

Younger patients' tumors had a different cellular makeup

The study's researchers couldn't definitely state that colon cancer in younger patients is always more aggressive — that would require more study.

However, what they did find was that younger patients "generally have more aggressive disease and they are generally more resistant to the standard of care therapies, which is mostly chemotherapy," Anderson said.

Tumors in younger patients generally had a higher presence of supporting and connecting cells known as stromal cells. Stromal cells, such as fibroblasts, can produce factors that suppress the immune response, making it harder for chemotherapy drugs to work. "They essentially can form a shield that protects the tumor from infiltration," Anderson said.

The study found that the presence of stromal cells generally declined from younger to older patients, and the youngest patients tended to have the highest number of stromal cells in proportion to cancer cells.

The reverse was true for the oldest patients, who generally had the fewest stromal cells and the highest numbers of cancer cells.

Researchers narrowed down where to look for answers

Younger patients also had higher activity of long non-coding RNAs (lncRNAs), which are associated with cellular signaling in cancer. The study also found gene activity in younger patients that suggested stronger signaling between cells — potentially helping cancer cells move and invade nearby tissue.

The problem is, lncRNAs are still a fairly recent discovery; they only became linked to cancer research in the late 2000s, with some poorly understood ones referred to as "dark RNAs." "A lot of them have just not been researched, and that's why they're called 'dark RNAs' — it's a big mystery," Anderson said.

For that reason, she said it was the finding she considered most promising. "There's a world of biology to be discovered there — we know where to focus our research efforts," she said.

Anderson, an immunologist, also hopes to explore the presence of immune cells in younger colon cancer cases, as immune cells are involved in killing cancer cells but were "under-captured" in this study, she said. "There are many types of immune cells," she said. "Are there different subsets that are more present in the young tumors or absent in the young tumors versus the older tumors?"

Reduce your risk with these simple habits

While the study doesn't present any immediate new takeaways for young people concerned about colon cancer, Anderson suggested following existing guidance for lowering your risk.

She noted that the recommended screening age for most people was lowered from 50 to 45 a few years ago, but that it's wise to see a doctor sooner if you experience common colon cancer symptoms like rectal bleeding, abdominal pain, bloating, or changes in bowel movements.

If you're "extra cautious," she said, it's never a bad idea to stay active and cut down on inflammatory foods such as ultraprocessed snacks and alcohol.