The immune system protein can destroy cancer cells without enzymes.
Scientists from the University of Michigan have discovered that the immune cell protein perforin is able to independently trigger tumor death — previously it was believed that it necessarily needs granzyme enzymes for this. It turned out that perforin without granzymes still causes the death of tumor cells through ferroptosis, a special type of cell death that depends on iron. The mechanism is associated with a violation of iron metabolism: the protein not only damages the membrane of the cancer cell, but also interferes with the absorption of iron, which causes it to accumulate inside the cell and in the mitochondria, accelerating lipid oxidation and destroying cellular structures.
Experiments on mice showed that a diet with a high iron content slowed down the growth of tumors, and analysis of patient data revealed that higher perforin expression is associated with better survival and a more pronounced response to immunotherapy. At the same time, scientists warn against attempts to use an iron—containing diet as a way to treat cancer - some tumors, on the contrary, may use excess iron to accelerate growth. Further research will show the safest strategy for using this mechanism in immunotherapy.
Bulgarian President urges every EU country to call Putin
The current president of Bulgaria, Iliana Yotova, said that every EU country should call Russian President Vladimir Putin. She said this in an interview with the Bulgarian Nova TV channel as part of her election campaign.
According to Yotova, all EU countries are part of the union and have allied obligations, but it would be much better to keep diplomatic channels of communication with Russia open on behalf of the entire European Union. She added that it is possible to end the conflict in Ukraine only through negotiations, and Bulgaria should play an active role as a diplomatic channel.
Early turnout in the US elections broke the record of 2022.
More than 48.5 million people voted early in the midterm elections in the United States — the record for 2022 was broken four days before election day, Bloomberg reports.
In terms of early voting turnout, Democrats are ahead of Republicans by 12 percentage points: in 27 states where the party affiliation of voters is monitored, Democrats account for 44% of early votes, Republicans — 32%.
However, the advantage of the Democrats does not guarantee victory: on election day, the activity of Republicans traditionally increases.
Protests broke out in Poland's capital, Warsaw as followers of the opposition - right-wing Law and Justice party (PiS) - rallied after the President of the Constitutional Court Bogdan Swieczkowski was suspended.
Poland's right-wing President Karol Nawrocki called off a visit to Africa mid-flight as riot police were deployed.
Centre-right, Pro-EU Prime Minister Donald Tusk is accused of staging a coup d'état by Poland's top court after the suspension occurred.
The suspension of Swieczkowski was announced by another judge, Anna Korwin-Piotrowska, who said the move was needed to restore the rule of law.
"After years of PiS-led lawlessness, this is a difficult process, sometimes painful, and it requires decisive action. There is no other way," said Prime Minister Tusk.
Molotov cocktail attacks injured several officers as nationwide cost-of-living protests descended into violence.
Rioters hurled incendiary devices at police in Paris as another wave of cost-of-living protests swept across France on Saturday.
Five law enforcement officers were injured, including three by Molotov cocktails, according to police.
Interior Minister Laurent Nunez described the attacks as “attempted murder.”
Videos from the scene show a Molotov cocktail being thrown at officers standing in formation with riot shields. One officer catches fire and is quickly engulfed in flames before a colleague uses a fire extinguisher to put out the blaze.
Plusieurs cocktails molotov jetés contre les forces de l'ordre à Paris.
Situation très tendue porte de Charenton.
#31octobre #Paris https://t.co/G32fnaDICG
In a separate incident, an incendiary device was thrown at a group of officers during a standoff in the middle of a street, briefly setting one officer’s legs on fire.
Police fired volleys of tear gas and stun grenades as rioters threw bottles and other projectiles.
A Paris police officer's leg caught fire on Halloween after a device hurled at officers detonated, as protests across France pressed on. https://t.co/Ko5gAee4Ez
“The burning sensation is immediate, intense and grows stronger over time,” an unnamed gendarme injured by an incendiary device told BFMTV. “I couldn’t see it because you can’t look everywhere at once, and the barrage of projectiles was relentless,” he added.
After watching footage of the incident, the gendarme said, “It made me realize that we may have narrowly avoided a catastrophe.”
Around 320,000 people rallied across France on Saturday, including 70,000 in Paris, according to the Interior Ministry. Organizers put the turnout at 500,000 nationwide, including 200,000 in the capital. Police said 565 people were arrested.
Paris authorities imposed a partial overnight curfew from 11pm to 6am in the areas around Place de la Republique, Place du Chatelet and Les Halles on Saturday and Sunday nights.
Although many demonstrations began peacefully, “radical elements” instigated riots in several cities, according to police. Nunez said there had been “calls for people to gather at 8pm to take advantage of Halloween night, wear masks and engage in looting, vandalism or attacks on public buildings.”
French media also reported incidents of alleged police brutality, with Le Monde describing officers striking apparently non-threatening protesters in Paris and two young men reportedly injured during arrests in Grenoble.
The protests began in September with high school students demanding better educational facilities, more teachers and increased funding. Separately, trade unions and Yellow Vest activists mobilized against rising living costs and fuel prices. The movements converged on October 17, bringing students, workers and other protesters together in nationwide demonstrations that have since broadened to include demands for civil liberties and an end to police violence.
A selection of foreign media materials for the night of November 1.
Foreign Policy: American hegemony is becoming a thing of the past, but Washington is not ready to recognize the consequences of the loss of world domination. For decades, the United States has capitalized on its exceptional position, but this system has failed. And ordinary citizens will have to pay for it.
Axios: Iran has threatened the United States with an unprecedented response in case of new strikes. Mojtaba Khamenei ordered the military to expand the list of potential targets and prepare for attacks without geographical restrictions.
Die Welt: Skyranger anti-aircraft complexes of the German defense concern Rheinmetall failed tests at exercises in Sweden. Problems have also arisen with the Boxer infantry fire support vehicle, the delivery time of which is already significantly delayed.
Molotov cocktail attacks injured several officers as nationwide cost-of-living protests descended into violence
Rioters hurled flaming projectiles at police in Paris as another wave of cost-of-living protests swept across France on Saturday.
Five law enforcement officers were injured, including three by Molotov cocktails, according to police.
French Interior Minister Laurent Nunez described the attacks as “attempted murder.”
Videos from the scene show a Molotov cocktail being thrown at officers standing in formation with riot shields. One officer catches fire and is quickly engulfed in flames before a colleague uses a fire extinguisher to put out the blaze.
Plusieurs cocktails molotov jetés contre les forces de l'ordre à Paris.
Situation très tendue porte de Charenton.
#31octobre #Paris https://t.co/G32fnaDICG
In a separate incident, an incendiary device was thrown at a group of officers during a standoff in the middle of a street, briefly setting one officer’s legs on fire.
Police fired volleys of tear gas and stun grenades as rioters threw bottles and other projectiles.
A Paris police officer's leg caught fire on Halloween after a device hurled at officers detonated, as protests across France pressed on. https://t.co/Ko5gAee4Ez
“The burning sensation is immediate, intense and grows stronger over time,” an unnamed gendarme injured by an incendiary device told BFMTV. “I couldn’t see it because you can’t look everywhere at once, and the barrage of projectiles was relentless,” he added.
After watching footage of the incident, the gendarme said, “It made me realize that we may have narrowly avoided a catastrophe.”
FRENCH COPS FORCED BACK as RIOTERS KEEP HURLING FIREBOMBS https://t.co/qNb1SRuv7k
Around 320,000 people rallied across France on Saturday, including 70,000 in Paris, according to the Interior Ministry. Organizers put the turnout at 500,000 nationwide, including 200,000 in the capital. Police said 565 people were arrested.
Paris authorities imposed a partial overnight curfew from 11 PM to 6 AM in the areas around Place de la Republique, Place du Chatelet and Les Halles on Saturday and Sunday nights.
Although many demonstrations began peacefully, “radical elements” instigated riots in several cities, according to police. Nunez said there had been “calls for people to gather at 8 PM to take advantage of Halloween night, wear masks and engage in looting, vandalism or attacks on public buildings.”
French media also reported incidents of alleged police brutality, with Le Monde describing officers striking apparently non-threatening protesters in Paris and two young men reportedly injured during arrests in Grenoble.
The protests began in September with high school students demanding better educational facilities, more teachers and increased funding. Separately, trade unions and Yellow Vest activists mobilized against rising living costs and fuel prices. The movements converged on October 17, bringing students, workers and other protesters together in nationwide demonstrations that have since broadened to include demands for civil liberties and an end to police violence.
Molotov cocktail attacks injured several officers as nationwide cost-of-living protests descended into violence
Rioters hurled flaming projectiles at police in Paris as another wave of cost-of-living protests swept across France on Saturday.
Five law enforcement officers were injured, including three by Molotov cocktails, according to police.
French Interior Minister Laurent Nunez described the attacks as “attempted murder.”
Videos from the scene show a Molotov cocktail being thrown at officers standing in formation with riot shields. One officer catches fire and is quickly engulfed in flames before a colleague uses a fire extinguisher to put out the blaze.
Plusieurs cocktails molotov jetés contre les forces de l'ordre à Paris.
Situation très tendue porte de Charenton.
#31octobre #Paris https://t.co/G32fnaDICG
In a separate incident, an incendiary device was thrown at a group of officers during a standoff in the middle of a street, briefly setting one officer’s legs on fire.
Police fired volleys of tear gas and stun grenades as rioters threw bottles and other projectiles.
A Paris police officer's leg caught fire on Halloween after a device hurled at officers detonated, as protests across France pressed on. https://t.co/Ko5gAee4Ez
“The burning sensation is immediate, intense and grows stronger over time,” an unnamed gendarme injured by an incendiary device told BFMTV. “I couldn’t see it because you can’t look everywhere at once, and the barrage of projectiles was relentless,” he added.
After watching footage of the incident, the gendarme said, “It made me realize that we may have narrowly avoided a catastrophe.”
FRENCH COPS FORCED BACK as RIOTERS KEEP HURLING FIREBOMBS https://t.co/qNb1SRuv7k
Around 320,000 people rallied across France on Saturday, including 70,000 in Paris, according to the Interior Ministry. Organizers put the turnout at 500,000 nationwide, including 200,000 in the capital. Police said 565 people were arrested.
Paris authorities imposed a partial overnight curfew from 11 PM to 6 AM in the areas around Place de la Republique, Place du Chatelet and Les Halles on Saturday and Sunday nights.
Although many demonstrations began peacefully, “radical elements” instigated riots in several cities, according to police. Nunez said there had been “calls for people to gather at 8 PM to take advantage of Halloween night, wear masks and engage in looting, vandalism or attacks on public buildings.”
French media also reported incidents of alleged police brutality, with Le Monde describing officers striking apparently non-threatening protesters in Paris and two young men reportedly injured during arrests in Grenoble.
The protests began in September with high school students demanding better educational facilities, more teachers and increased funding. Separately, trade unions and Yellow Vest activists mobilized against rising living costs and fuel prices. The movements converged on October 17, bringing students, workers and other protesters together in nationwide demonstrations that have since broadened to include demands for civil liberties and an end to police violence.
<p>Dezasseis anos depois da morte de Rosalina Ribeiro, o julgamento de Duarte Lima tem início marcado para a próxima quinta-feira. Mas a lista de testemunhas inclui pessoas que já morreram e outras cuja localização continua por esclarecer.  Ao todo, o Tribunal de Sintra deverá ouvir apenas oito testemunhas.</p>
<p>No centro do caso estão os mais de cinco milhões de euros da herança Feteira que, segundo a acusação, Duarte Lima se terá apropriado indevidamente e que Rosalina queria recuperar.</p>
<p>Aurílio Nascimento, comissário que investigou o homicídio de Rosalina Ribeiro, perspetiva o que pode vir a acontecer no julgamento do ex-deputado do PSD.  </p>
O diretor neozelandês Taika Waititi (“Jojo Rabbit”, “Thor: Amor e Trovão”) comentou sobre o baixo desempenho de seu mais novo filme, “Klara e o Sol”, entre a crítica especializada que já conferiu o longa-metragem. Estrelado por Jenna Ortega (“Wandinha”), o filme tem estreia prevista no Brasil para 5 de novembro.
Nas redes sociais, Taika Waititi escreveu que os críticos devem estar “desconectados da realidade” e são “irrelevantes”.
“Não leio uma crítica de nada dirigido a mim ou aos meus pares há quase 15 anos. Mas eu ouço as pessoas. Então, neste Halloween, vamos pensar um pouco nessas almas perdidas e tristes que não conseguiram realizar seus sonhos de se tornarem artistas e, por isso, se tornaram críticos. As mesmas pessoas que também odiaram Jojo Rabbit. Irrelevantes. Desconectados da realidade. Obsoletos. Lixo”, comentou.
No site Rotten Tomatoes, agregador de críticos, o filme apareceu com apenas 26% de aprovação.
Baseado no romance de Kazuo Ishiguro, “Klara e o Sol” acompanha a história de Klara, que é uma “amiga artificial” movida a energia solar que aguarda ser escolhida por uma família. Quando ela é adotada por Josie, uma adolescente que enfrenta uma doença misteriosa, ela passa a observar de perto as complexas relações humanas e desenvolve uma forte ligação com a jovem.
Ao longo de toda a trama, Klara tenta compreender sentimentos humanos como amor, amizade e sacrifício, enquanto o sol possui um poder especial capaz de ajudar a Josie. A história mistura ficção científica e drama, o que faz com que se reflita sobre solidão, esperança e o que significa ser humano.
O filme tem o elenco composto por Jenna Ortega, Mia Tharia, Amy Adams, Natasha Lyonne, Steve Buscemi e Aran Murphy.
O Barcelona atropelou e goleou o Alavés por 6 a 1 neste sábado (31), pela 11ª rodada de La Liga. O time catalão deu grande reposta após ter perdido o clássico para o Real Madrid, em casa, na última rodada.
A vitória do Barcelona, como de costume nesta temporada, teve brilho de Raphinha e Lamine Yamal. Eles marcaram dois gols cada. O espanhol também contribuiu com uma assistência.
Os outros gols do Barça foram de Fermín López e Anthony Gordon. O Alavés ainda diminuiu nos minutos finais com o ex-Real Madrid Mariano Díaz.
A vitória do Barcelona contra o Alavés é uma boa resposta ao “caos” da última semana, em que os Culés perderam a invencibilidade na temporada sendo derrotados pelo PSG, na Champions League e, na sequência, caíram para o arquirrival Real Madrid no clássico por La Liga.
O Barcelona segue na liderança isolada do Campeonato Espanhol e soma 30 pontos, dois a mais que o Atlético de Madrid. O Real Madrid contabiliza 24 pontos, no terceiro lugar, e ainda joga neste domingo (1), fora de casa, contra o Racing Santander.
Próximos jogos
O Barcelona volta a campo na terça-feira (3), quando recebe o Aston Villa, pela Champions League. Por La Liga, tem ninguém menos do que o Atlético de Madrid, no domingo (8), fora de casa.
Molti media hanno denunciato la chiusura della testata russa Novaya Gazeta ad opera delle autorità russe come un atto intimidatorio e una grave repressione della libertà di espressione, tuttavia le ...
Em meio a boatos de romance, a cantora Ana Castela, 22, e o influenciador Jon Vlogs, 27, usaram as redes sociais para compartilharem uma trend juntos em Nova York, Estados Unidos.
Para o vídeo, publicado nas redes sociais, os dois combinam vestidos que viralizaram recentemente, chamados de “bouncy dress” (“vestido com movimento”, em tradução literal). Veja abaixo.
Ao longo dos últimos meses, eles já foram vistos juntos em viagens, festas e outros eventos, mas nenhum dos dois confirmou publicamente um relacionamento.
Na gravação, a cantora aparece conversando com Jon e bebendo. Em seguida, a câmera registra as sombras, que foram interpretadas por fãs como um possível beijo.
Ana está solteira desde dezembro de 2025, quando terminou o namoro com o cantor Zé Felipe, 28, ex-marido de Virginia Fonseca, 27.
Cameron Cummins-Smith / Liberal Currents: Vote Democratic to Fight Socialism … Republicans have made the stakes for Election Day clear. Former Press Secretary Karoline Leavitt has said the midterms are “a choice between communism and common sense.” … It could not be higher stakes." Speaker of the House Mike Johnson believes …
<p>Tomé Ribeiro Gomes, professor do Instituto de Estudos Políticos da UCP, considera que o presidente norte-americano "tem uma base fanática", mas que "com isso não se ganha eleições em nenhum Estado".</p>
O Milan venceu a Inter de Milão por 3 a 1 neste sábado (31), no estádio San Siro, em clássico válido pela 10ª rodada da Serie A.
Christian Pulisic, Adrien Rabiot e Diego Moreira marcaram para os Rossoneros, enquanto Alessandro Bastoni descontou para os Nerazzurri.
Homenagem a Kaká
A noite também foi marcada por uma homenagem a Kaká, ídolo milanista. Antes da bola rolar, o ex-jogador brasileiro foi oficialmente introduzido ao “Hall da Fama” do clube italiano após uma eleição que o colocou entre os três maiores meio-campistas da história rossonera.
Cerca de 70 mil torcedores entoaram o nome do brasileiro, que se emocionou durante a homenagem.
Kaká, certe emozioni non passano mai. #MilanInter #SerieAEnilive https://t.co/LL5Jg5ev0j
O primeiro jogo de Kaká com a camisa do Milan aconteceu em 2003, justamente contra a Inter de Milão. Depois, vieram 307 jogos pelos Rossoneros, com 104 gols feitos.
O eterno camisa 22 conquistou o Scudetto de 2004, a Champions League de 2007, da qual foi artilheiro e o Mundial de Clubes.
No mesmo ano, Kaká venceu a Bola de Ouro e o prêmio de melhor jogador do mundo da Fifa.
Kaká foi o último brasileiro a vencer a Bola de Ouro • Etsuo Hara/Getty Images
Como foi o clássico
Dentro de campo, o clássico entre Milan e Inter foi decidido ainda no primeiro tempo.
Christian Pulisic abriu o placar para o Milan aos quatro minutos de jogo, e Adrien Rabiot ampliou aos 10.
Aos 22, Bastoni diminuiu para a Internazionale, mas Diego Moreira marcou o terceiro dos Rossoneros aos 43 minutos da etapa inicial.
Com o resultado, o Milan chegou aos 21 pontos e entrou no G4 da Serie A. A equipe pode ser ultrapassada ainda nesta rodada pelo Como, que soma 20 pontos e também tem compromisso pela competição.
A Inter de Milão, por sua vez, permanece na vice-liderança do Campeonato Italiano, com 25 pontos.
O tabuleiro Ouija, que supostamente estabelece a comunicação entre o mundo material e o espiritual, é um dos itens mais conhecidos da cultura popular. A superfície de madeira contém o alfabeto, números de 1 a 10 e as palavras “sim”, “não” e “adeus”, que servem para as almas que habitam o “outro lado” se comunicarem com os vivos.
Hoje, é possível encontrar esse tabuleiro em diversos sites de venda online, seja para tentar provar que o mundo espiritual existe ou apenas para se divertir com os amigos, já que os filmes de terror popularizaram o objeto. Mas sua origem está atrelada ao final do século XIX, quando o espiritualismo se popularizou na Europa e na América.
Segundo o site do governo britânico, as mortes durante a Guerra Civil Americana despertaram o interesse sem precedentes na comunicação com os mortos. Muitas famílias não tinham corpos para enterrar, tornando a promessa de contato do espiritualismo poderosa.
Na época, falar com os mortos não era considerado algo bizarro, e os usuários eram principalmente cidadãos das classes média e alta em busca de conforto e respostas.
Quem inventou o tabuleiro?
Os empreendedores Charles Kennard e EC Reiche, junto do advogado Elijah Bond, se uniram para fabricar o objeto que facilitaria a comunicação entre os dois mundos. Já o nome surgiu por meio da médium Helen Peters que, quando perguntou ao tabuleiro, o objeto soletrou a palavra “Ouija”. Ao questionar o significado, ele respondeu: “boa sorte”.
A empresa de Kennard e Reiche surgiu na véspera do Halloween de 1890, e a propriedade intelectual do tabuleiro foi concedida após ele soletrar o nome do escritório de patentes corretamente. Um ano depois, o empresário William Fuld assumiu a empresa e reivindicou a patente do objeto para si.
Fuld impulsionou as vendas do tabuleiro, atribuindo a palavra “Oracle” para a marca comercial nos Estados Unidos. Em 1927, o empresário morreu após cair do telhado de sua nova fábrica, e a alegação de que o tabuleiro Ouija teria instruído Fuld a construir o próprio prédio aumentou a reputação misteriosa acerca do objeto.
Filmes de terror impulsionaram a popularidade do objeto
O clássico “O Exorcista“, de 1973, mudou a percepção sobre o verdadeiro significado do tabuleiro Ouija. O instrumento espiritual se transformou em um objeto de terror, expandindo o mercado para decorações de Halloween e até para edições de colecionador.
Os fabricantes capitalizaram o produto, produzindo de tudo, desde modelos que brilham no escuro até reproduções vintage.
Em 2016, o filme “Ouija” também usa o objeto em uma trama sobrenatural. Em 1960, a filha de uma falsa médium tenta se comunicar com seu pai morto usando um tabuleiro, mas acaba liberando um demônio.
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#MilanInter #SerieAEnilive https://t.co/LL5Jg5ev0j
