Written by Ralf Drachenberg, Annastiina Papunen and Rebecca Zamponi.

General

The European Council will be preceded by pre-summit meetings of European political parties with their respective affiliated EU leaders. Additionally, a group of ‘like-minded’ countries on migration will also meet prior to the start of the meeting. Following a similar pattern, a new group of 17 leaders, including Germany, Belgium and Italy, met by videoconference on 8 June to discuss competitiveness issues.

As usual, the European Council meeting will start with an address by the President of the European Parliament, Roberta Metsola. For the first time, the report of the rotating Council Presidency on the follow-up to the previous European Council conclusions will be given in the presence of the European Parliament President. This report by Cypriot President Nikos Christodoulides will include an overview of the implementation of the ‘One Europe, One Market’ roadmap signed in the margins of the informal meeting of Heads of State or Government in Cyprus in April 2026.

The membership of the European Council has evolved since the last European Council meeting. With the departure of Viktor Orbán, Emmanuel Macron is now the longest serving European Council member continuously in office (since 2017).

European Council meeting

Ukraine

The discussion on Ukraine will start with an exchange of views with Ukrainian President Volodymyr Zelenskyy, who on 4 June 2026 published an open letter to President Vladimir Putin, proposing to end the war through direct engagement between the two leaders. The proposed meeting would take place in a neutral location ‘with active US and European participation’ and ‘the front line today [as] the line from which diplomacy must begin.’. Three days after the letter, President Zelenskyy issued a joint statement with the leaders of France, Germany and the United Kingdom, outlining five conditions for just and lasting peace.Thus, EU leaders may express the EU’s readiness to step up its engagement in peace negotiations.

In his invitation letter to EU leaders, European Council President António Costa underlined the effectiveness of the EU’s ‘two-pronged approach – supporting Ukraine and increasing pressure on Russia’. Concerning support for Ukraine, the European Council is expected to discuss intensifying efforts to rebuild critical energy and civilian infrastructure as well as accelerating the production and delivery of military equipment, notably ammunition, drones and missiles. As regards pressure on Russia, the European Council could reiterate the importance of weakening Russia’s economy and thus its ability to wage war. Following the unveiling of the 21st package of sanctions, which targets heavily the country’s banking system and crypto networks, EU leaders may call for swift adoption of the new package. In parallel, after asking in March 2026 for ‘the potential threat posed to the EU’s internal security by Russian ex-combatants having participated in the aggression against Ukraine to be assessed, the European Council could ask for further work to be carried out to address this threat, and possibly consider banning Russian citizens having served in the country’s armed forces since 2022 from entering EU territory. In addition, the call by 11 Schengen countries for stricter visa rules for all Russian citizens – which follows a surge in visas issued to Russian tourists in 2024 and 2025 – may also be raised.

Although not formally on the agenda, the topic of enlargement could turn out to be the subject of broader discussions. First, because EU leaders are likely to welcome the holding of the Intergovernmental Conference on the accession of Ukraine, and Moldova, to the European Union, and the agreement to open the fundamentals cluster on 15 June 2026. Second, because EU leaders may wish to underline the ‘new impetus’ given to the enlargement process at the EU-Western Balkans Summit in Montenegro on 5 June and reiterate their support for the region’s path to EU membership in line with a merit-based approach. Third, because, after the Franco-German initiative of 4 June 2026 suggesting ways of gradually integrating candidate countries into the EU, the European Council may wish to discuss the ‘new ideas to streamline and accelerate the process,’ which, as President Costa stressed, are currently under consideration. German Chancellor Friedrich Merz had previously addressed a letter to Presidents Costa, von der Leyen, and Christodoulides, proposing to grant Ukraine ‘associate member status’, while offering ‘observer status’ and access to the single market to Western Balkan countries.

Middle East

The European Council is expected to discuss the constantly evolving situation in Iran and the wider Middle East region. After the announced memorandum of understanding between Iran and the United States, which envisages an ‘immediate and permanent’ end of military operations on all fronts, including in Lebanon, EU leaders may welcome the peace agreement and the toll-free reopening of the Strait of Hormuz. Due to be signed on 19 June, the agreement plans to ease sanctions and begin negotiations over nuclear issues. In a joint statement, the leaders of France, Germany, Italy, Cyprus and Greece, as well as Australia, Canada and the United Kingdom, expressed their readiness also to lift sanctions imposed on Iran and work ‘with the US, Iran and regional partners to … achieve a long-term diplomatic settlement’. Ahead of the G7 summit in Evian, President Costa signalled the EU’s willingness to contribute to a global strategy for a lasting peace in the Middle East. In that context, EU leaders are likely to discuss preparations under way aimed at guaranteeing the freedom of navigation in the Strait, and consider a possible reinforcement of the mandate of the EU maritime defensive operation, EUNAVFOR ASPIDES.

The European Council will also discuss the situation in Gaza and the West Bank. On Gaza, they may touch upon the preparation of restrictive measures against Israelis due to the treatment of activists who were bringing aid to Gaza. A number of Member States have increasingly become critical of Israel following the interception of the Global Sumud Flotilla in international waters and the mistreatment of those on board, who included a number of EU citizens. As a result of the incident, Italy, which has previously blocked attempts to suspend the EU-Israel Association Agreement, called for sanctions against the Israeli Minister of National Security, Ben-Gvir. However, it remains unlikely that EU leaders will reach a unanimous agreement on calling for sanctions against a sitting Israeli Minister ahead of upcoming Israeli elections. Additionally, in the context of the EU leaders’ reiterated condemnation of unilateral Israeli action aimed at further expanding illegal settlements, the concerns expressed by several Member States regarding products from illegal Israeli settlements entering the European market may also be raised.

Next multiannual financial framework

Following a first discussion in April 2026, EU leaders will hold an exchange of views on the 2028-2034 MFF based on a new negotiating box with figures drawn up by the current Cyprus Council Presidency.

On the MFF, the dividing lines in the European Council are normally between the net contributors and the net beneficiaries.[1]The former group includes Denmark, Germany, France, Austria, the Netherlands, Finland and Sweden; some of these Member States are known as the ‘frugals‘. The net beneficiaries meet under the name ‘friends of cohesion’ and include Bulgaria, Czechia, Estonia, Greece, Spain, Croatia, Italy,[2] Latvia, Lithuania, Hungary, Malta, Poland, Portugal, Romania, Slovenia and Slovakia.These two groups meet separately ahead of meetings in the Council, and sometimes the European Council, to coordinate their positions before the main meeting. Cyprus, as the current Council Presidency, and Ireland, which will take over on 1 July, do not formally attend these meetings, in order to remain ‘an honest broker’.

As in negotiations for previous MFFs, the usual dividing lines concern i) the size of the EU budget, ii) the balance between policy areas, iii) the existence and size of rebates, and iv) new own resources. An additional topic is the pace of repayment of the joint debt resulting from the EU recovery plan (i.e. Next Generation EU).

Regarding the size of the EU budget, the European Commission proposed a long-term budget of €1.789 trillion (in commitments over seven years in constant 2025 prices). While the European Parliament suggested in its interim report of 28 April 2026 a nominal increase of €175.11 billion (2025 constant prices) to this proposal, the frugal Member States have demanded to reduce the spending proposed by the Commission. The new negotiating box of the Cyprus Council Presidency, which only suggests an overall reduction of around 2 % of the original Commission MFF proposal, has received substantial criticism by the frugal Member States, the latter even expressing doubt over the Cyprus Presidency’s capacity to act as a ‘true honest broker’.

As regards the balance between policy areas, the friends of cohesion have, in a joint declaration of 25 May 2026, argued that the next MFF needed to provide sufficient resources for the cohesion policy, common agricultural policy and common fisheries policy. While some net contributors like Denmark, Germany, the Netherlands, Austria and Sweden have rejected this proposal, others such as France and Ireland were less opposed. In Chancellor Merz’s view, EU spending must be modernised to focus on investment in defence and competitiveness, with cuts to traditional farming and regional subsidies.

On the third point, the budget correction mechanisms – or ‘rebates’ – have been used in the EU’s long-term budget since the 1980s to compensate certain Member States for their financial contributions to the long-term EU budget. The suggestion to abolish these rebates has been put forward in several previous MFF negotiation rounds but has never been followed up on. In their joint declaration, the friends of cohesion have also called for the abolition of rebates, arguing that ‘there is no political or economic rationale for re-introducing them’.

Finally, on new own resources, the Commission submitted a proposal on 16 July 2025 suggesting new own resources on i) a corporate resource for Europe; ii) a tobacco excise duty own resource; iii) a share of the proceeds of the emissions trading system; iv) the carbon border adjustment mechanism; and v) a contribution on non-collected e-waste. At a discussion of EU finance ministers in October 2025, Ireland, Hungary, Finland and Sweden rejected outright any introduction of new own resources, while others such as Czechia and Poland criticised specific new own resources. In April 2026, the European Parliament put forward proposals on future own resources, suggesting to tax digital services, online gambling and crypto-assets. After the April 2026 informal meeting of EU leaders, President Costa signalled openness to considering the suggestions of Parliament, even if concerns have subsequently been expressed over their technical feasibility.

Closely related to discussions on the revenue side of the MFF are ideas put forward by President Macron and Greek Prime Minister Kyriakos Mitsotakis in favour of new common borrowing and a rollover of the pandemic debt to finance the bloc’s shared priorities.

No decisions are expected at this European Council meeting; President Costa’s objective is to give further guidance to the incoming Irish Council Presidency as to the type of new own resources on which a compromise could be achievable. While President Costa has insisted on EU leaders agreeing by the end of 2026 – a timeline expected to be reflected in the conclusions – many Member States have expressed doubts over the feasibility of this timetable.

Global economic challenges

In an extremely challenging geoeconomic environment, EU leaders will hold a strategic debate over dinner on the global macroeconomic imbalances and their impact on EU competitiveness. Previously, in December 2025, they held a similar discussion on ‘Geoeconomy and competitiveness’. However, in six months, the global environment has altered significantly; as President Costa underlined, the discussion will thus aim to ‘develop a common understanding of the challenges and to provide guidance to the Commission on the way forward’. On the one hand, EU leaders will look at ways of strengthening the EU’s strategic autonomy and competitiveness, but at the same time emphasise that fair competition at global level needs to be guaranteed.

In that context, without explicitly mentioning the country, Costa may intend to raise the issue of trade relations with China. Ahead of the European Council meeting, the EU foreign ministers discussed the topic in their meeting on 15 June, while ‘global imbalances’ are also likely to feature on the agenda of the G7 meeting in Evian, France on 15-17 June. The EU has defined China as a partner, a competitor and a systemic rival. China is the EU’s third largest trading partner in goods and services after the US and UK, and the EU and China together account for 29.6 % of global trade. There is a long-standing trade deficit between the EU and China; most recently, the EU has been worried about a possible ‘China Shock 2.0‘, i.e. the large influx of state-subsidised exports of Chinese products such as electric vehicles, batteries and solar panels, as well as steel and chemicals. In March, five EU Member States (France, Italy, Spain, the Netherlands and Lithuania) wrote a joint non-paper calling for tougher measures to counter abusive trade practises, without explicitly mentioning China.

Before dinner, EU leaders are expected to review progress made with the ‘One Europe, One Market’ agenda and the related roadmap, signed on the sidelines of the informal meeting in Cyprus in April. Thus, they will take stock of action aimed at strengthening the single market, enabling Europe’s industrial renewal, simplifying rules, reducing dependencies and encouraging innovation and investment. In the context of ongoing wars in Iran and Ukraine, which have disrupted global supply chains and fundamentally reshaped the EU energy markets, EU leaders envisaged in their March conclusions to return to the issues of affordable energy prices and the Energy Union 2030. They will probably review progress in ‘achieving Europe’s strategic autonomy, strengthening resilience, structurally lowering energy prices, and delivering the clean, abundant and home-grown energy needed to power the economy of the future’.

Although not officially on the agenda, the latest AI models and the challenges they may pose to EU citizens, companies and critical infrastructure may be discussed on the sidelines. US company Anthropic announced in April that it had built a new model, Claude Mythos, which was too powerful to be released to the public due to its extraordinary ability to identify security vulnerabilities in critical software, such as financial and healthcare systems and electricity networks. As a follow-up, the company created Project Glasswing with the aim of securing the most critical software by initially giving some 50 organisations access to the model so that they could identify and fix security problems. The European Commission has been in talks with the company to secure access to EU actors, and especially European banks have been vocal about the topic. On 2 June, the access was expanded to 150 new organisations, including the EU cybersecurity agency ENISA. However, on 12 June, the US administration ordered Anthropic to suspend access to Mythos 5 and Fable 5 models from all foreign nationals, citing national security concerns. This led to Anthropic shutting access to these two models from all customers. Following these developments, there were increasing calls in the EU to speed up the work on technology sovereignty.

European defence and security

Considering ‘Russia’s increasingly reckless and irresponsible behaviour towards EU Member States’, stressed by Costa in his letter to EU leaders, the latter may condemn Russia’s numerous violations of European airspace recently, such as in Romania and Latvia. They are also likely to reiterate the importance of the EU defence readiness agenda, in particular efforts to increase air defence and drone capacity. In that context, EU leaders could welcome the work in the Council on the action plan on drone and counter-drone security.

According to the defence readiness roadmap, the Commission, in cooperation with the lead nations of the capability coalitions, should expand the strategic dialogue with industry, host the first annual Defence Industrial Summit and present an overview of the industrial capacity ramp-up needed to ensure reliable supply for the agreed capability areas by mid-2026. As projects were to be launched in all priority areas within the first half of 2026, EU leaders may evaluate the progress made on these and all other aspects relevant to the defence readiness agenda.

EU leaders may call on the Parliament and Council to make further progress on creating a military mobility area, the AGILE proposal (which seeks to enhance the EU’s capacity to deliver defence innovation more rapidly and effectively), and the defence readiness omnibus.

Migration

Migration has been discussed at every European Council meeting in this institutional cycle, apart from the special European Council on defence in March 2025. EU leaders will again take stock of progress in the implementation of its previous conclusions on migration – this just a few days after the entry into force of the EU migration pact on 12 June. Likewise, EU leaders might welcome the recent provisional agreement of Parliament and Council on changes to EU policy on the return of non-EU nationals staying illegally in the EU.

Fight against illicit drugs

For the first time, the European Council will address challenges linked to the use and trafficking of drugs. While this topic was not mentioned in the European Council’s Strategic Agenda 2024-2029, it features in the European Commission’s political guidelines. EU leaders are expected to provide guidance for the implementation of the EU drugs strategy and the related EU action plan proposed in December 2025 to respond to the growing health, security and societal challenges posed by drug use and trafficking.The EU drugs strategy is based on five pillars: (1) enhancing preparedness and response; (2) protecting public health; (3) improving security and protecting society; (4) addressing risks and harms; and (5) building strong partnerships. On 5 June 2026, Justice and Home Affairs Ministers endorsed the EU drugs strategy and the action plan, adopting conclusions on jointly operationalising them to deliver on the key priorities aimed at reducing drug use and drug-related harm.

European Semester

As is usual at the June European Council meeting, EU leaders will discuss the country-specific recommendations to allow the conclusion of the European Semester cycle. Published on 3 June, the European Semester spring package includes tailored recommendations to each Member State to improve their economic performance. The Council will proceed to the formal adoption of these recommendations after the European Council has discussed them.

Notes

[1] Net contributors to the EU budget are considered to be the Member States who contribute more to the EU budget than the amount of EU funding they receive, and vice versa for net beneficiaries.

[2] While Italy is a net contributing country, it is part of the friends of cohesion.

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Read the complete briefing on ‘Outlook for the European Council, 18-19 June‘ in the Think Tank pages of the European Parliament.

Eight years ago, Scott Hancock, then 28, helped a 19-year-old acquaintance, identified in court records as T.G., buy fentanyl. At her request, Hancock, who had been addicted to opioids for years, got in touch with his drug dealer, who gave him five capsules that he handed over to T.G. in exchange for $20. Then Hancock gave the money to his dealer. Because T.G. subsequently died from a fentanyl overdose, Hancock is serving a 20-year sentence at a federal prison in Illinois.

That was the mandatory minimum sentence under 21 USC 241, which prescribes penalties for drug distribution resulting in death. Although that law has been on the books since 1986, the dramatic increase in fentanyl-related deaths during the last decade prompted a surge in federal drug prosecutions involving overdoses, which rose by 44 percent between FY 2019 and FY 2023. Hancock's case was part of that trend, and it prompted his mother, G.D. Hancock, a retired finance professor, to delve into the subject, resulting in a database that sheds light on what happens when the government treats accidental deaths as homicides.

So far, Hancock has identified 2,930 sentences in such cases since 2010. That includes 1,399 federal cases and 1,531 state cases, which rely either on laws dealing specifically with drug-induced deaths or on more general statutes addressing felony murder, "depraved heart" homicide, or manslaughter.

Sentences of 20 years or more were pretty common at the federal level, accounting for 37 percent of the cases, compared to 13 percent at the state level. The vast majority of the cases (84 percent) were resolved by plea deals. That is not surprising, given the potential consequences of going to trial. While the median sentence for defendants who pleaded guilty was nine years, it was 20 years for defendants who insisted on making the government prove its case.

Hancock's tally is based on news reports, court records, announcements by state and federal prosecutors, her own "case files and research," and "cases sent in by families, lawyers and researchers." A separate database compiled by researchers at Northeastern University, drawn from news reports, includes 3,264 cases involving drug-induced homicide from 2011 to 2022.

These prosecutions are morally nonsensical. They treat people who voluntarily consume drugs as helpless victims of supposed predators who gave them the drugs they wanted. By similar logic, bartenders and liquor store owners should be held criminally liable whenever a customer succumbs to alcohol poisoning or the long-term effects of heavy drinking. The main difference is the legal status of the drug, which is arbitrary, politically determined, and historically contingent. And while illegal drugs pose special hazards, that is a result of prohibition, which creates a black market where product composition is highly variable and unpredictable.

Charging people with homicide based on accidental overdoses would be illogical and unjust even if the defendants were limited to actual drug dealers. But you can be charged with drug-induced homicide even if your "trafficking" consisted of nothing more than sharing drugs with a relative, romantic partner, friend, or acquaintance. Based on the information Hancock was able to glean, she counts 241 cases where the person who died from an overdose was the defendant's friend, partner, or family member, and other sources suggest such prosecutions are common.

The Northeastern University researchers analyzed a sample of 213 online news reports from 2000 to 2017. They found that 50 percent of defendants charged with drug-induced homicide were caretakers, family members, friends, or partners of the people who died.

In 2021, when the Pittsburgh Tribune-Review examined Pennsylvania prosecutions for "drug delivery resulting in death" (DDRD), it described a case involving "a Westmoreland County man" who "died from an overdose of drugs he'd gotten from a friend of a friend of a friend." Although "the drugs ultimately came from a man called 'Bee' in Penn Hills," the paper noted, "the three individuals between the victim and Bee were all charged" with DDRD, a first-degree felony punishable by up to 40 years in prison.

The Tribune-Review described several other DDRD defendants, including "a Delmont woman" who "called paramedics when she found her boyfriend unresponsive in their bathroom"; "two friends" who bought heroin for a man who overdosed at a Taco Bell; and "a Monessen woman" who "sent her cousin to buy a brick of heroin" and "sold five stamp bags to a friend, who then sold four bags to an Elizabeth Borough man who died from a fatal overdose."

The Tribune-Review also found that "many facing these charges are relatively low-level dealers." Jonathan Fodi, a defense attorney and former prosecutor, told the paper he and his colleagues had never seen a DDRD case involving a high-level dealer. Given the need to prove a link between the defendant and the person who died, that is not surprising. But that situation compounds the injustice of treating such deaths as homicides, since low-level dealers often do not know exactly what is in the drugs they are selling.

A 2002 analysis of 32 drug-induced homicide prosecutions, published in the New Jersey Law Journal, found that "25 involved prosecution of friends of the decedent who did not sell drugs in any significant manner." According to a 2017 report by a Wisconsin TV station that looked at the 100 most recent prosecutions for drug-induced homicide in that state, "nearly 90% of those charged were friends or relatives of the person who died, or the lowest people in the drug supply chain." When the Chicago Tribune examined drug-induced homicide cases filed between 2011 and 2014, it found "the defendant was typically the last person who was with the person who overdosed."

Even people who support the war on drugs should be able to recognize the injustice of sending people to prison for 10 or 20 years based on their tangential roles in deaths they neither caused nor intended. And far from making such deaths less likely, that policy impedes potentially lifesaving medical assistance because the risk of a homicide charge is apt to discourage bystanders from calling for help. That daunting deterrent undermines the goal of "Good Samaritan" laws that are supposed to shield 911 callers from criminal charges in such situations.

The official justification for these prosecutions is completely disconnected from the reality of the cases. "Deaths from illicit drugs, especially fentanyl, are at historic highs," the Drug Enforcement Administration (DEA) said in a 2023 press release. Because the DEA is "committed to protecting Americans and saving lives by pursuing those responsible," the agency explained, it aims to "make sure as many drug traffickers involved in those deaths as possible get an appearance in front of a judge."

As an example of that strategy, the DEA cited Scott Hancock's case, describing him as a "trafficker" who was "found guilty of providing the drugs that killed a 19-year-old woman in 2018." Given the details of that transaction, it is hard to see the logic here. Sending someone like Hancock to prison for 20 years has nothing to do with "saving lives."

The post How Helping Someone Buy Drugs Can Send You to Prison for 20 Years appeared first on Reason Magazine.

Patients who still need a medicine after taking part in a clinical trial must continue receiving it free from the trial’s sponsor, under rules published today. The protection applies when

The post Drug trial patients guaranteed continued free treatment under new rules appeared first on Portugal Resident.

World’s second largest brewer says use of drugs such as Wegovy can reduce desire to drink alcohol

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Heineken has warned British bars and pubs that the boom in popularity of weight-loss drugs could lead to a fall in sales of beer and cider.

The world’s second-largest brewer sent a presentation to British hospitality customers earlier this month that said the use of GLP-1 medication – such as Ozempic and Wegovy – could reduce the desire to drink alcohol. This in turn could result in “fullness and fewer serves” of pints in pubs and bars, it added.

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© Photograph: william87/Getty Images/iStockphoto

© Photograph: william87/Getty Images/iStockphoto

© Photograph: william87/Getty Images/iStockphoto

Two loaded Kalashnikov assault rifles, around 10,000 litres of fuel, nine vehicles and a speedboat were seized during a night of intense police operations targeting suspected maritime drug-trafficking networks across

The post Kalashnikovs and 10,000 litres of fuel seized in Portugal’s latest drug-trafficking crackdown appeared first on Portugal Resident.

Police authorities have seized 42 tonnes of cocaine since January this year, 17 more than in the whole of 2025, national director of the Judicial Police (PJ), Carlos Cabreiro, has

The post Cocaine seizures in Portugal “already exceed 42 tonnes” this year appeared first on Portugal Resident.

The federal drug police want to turn consumers of certain concentrated kratom-derived products into criminals while leaving traditional kratom leaf products outside the ban. Before exposing adults to arrest and prosecution, the feds owe them a scientific explanation for that distinction.

On October 14, the Drug Enforcement Administration (DEA) announced its intent to temporarily place 7-hydroxymitragynine (commonly called 7-OH) and mitragynine pseudoindoxyl—above specified thresholds—in Schedule I. Schedule I is the category for drugs that the agency thinks have "no currently accepted medical use" and "a high potential for abuse." A scheduling order could be issued on or after November 13.

The DEA already classifies mitragynine pseudoindoxyl as a Schedule I substance regardless of concentration. The proposal would ease that restriction by introducing thresholds—while imposing new Schedule I restrictions on 7-OH under the same criteria.

The Food and Drug Administration (FDA) and the Department of Health and Human Services (HHS) have supported the DEA's move, and HHS supplied the proposed thresholds. Under the temporary scheduling provision of the Controlled Substances Act, the DEA must consider HHS's comments but need not follow its recommendations. Congress gave a law-enforcement agency the authority to decide which drugs individuals may consume.

The ordinary scheduling process gives health officials more authority: HHS's scientific and medical findings bind the DEA, and its recommendation against control prevents the agency from proceeding. But temporary scheduling lets the DEA bypass those requirements when it determines a substance poses an imminent hazard to public safety.

Congress should never have given federal drug police that power. Having done so, it should at least demand compelling evidence before they exercise it.

Kratom comes from a Southeast Asian plant whose principal alkaloid is mitragynine. Its leaves contain trace amounts of 7-OH. Manufacturers also sell concentrated 7-OH products and products containing the related compound, mitragynine pseudoindoxyl.

Millions of Americans use kratom or kratom-derived products. A 2022 review cited an estimate of 2.1 million U.S. users in 2020. In a survey of 2,798 users, 91 percent reported using it for pain and 41 percent said they use it to reduce or stop opioid use. In a letter to HHS, nine military veterans described using 7-OH to manage pain and symptoms of post-traumatic stress disorder and to move away from other opioids and from alcohol. They warned that banning it could drive them back to more dangerous drugs.

These reports describe benefits that warrant further study and needs that will persist after a ban.

Concentrated 7-OH products deliver a potent alkaloid without requiring consumers to ingest large amounts of kratom leaf. 7-OH is significantly more potent than mitragynine in activating the opioid receptors involved in pain relief. Researchers still need to determine how its benefits and risks compare across different human doses.

The DEA's proposed criminal controls hinge on concentration and composition. The concentration threshold is 1 milligram per gram of solid material or 1 milligram per milliliter of liquid, calculated for the two covered substances combined. Products would also trigger controls if the mitragynine-to-covered-substances ratio fell below 100 to 1.

Consider a tablet containing 15 milligrams of 7-OH, a strength advertised by some sellers. If the tablet weighs one gram, its concentration exceeds the limit fifteenfold. Diluting the same 15 milligrams into a product weighing 15 grams brings it to the concentration limit. Consuming the entire product still delivers the same dose. It would also need at least 1,500 milligrams of mitragynine to avoid the separate ratio restriction.

Adding bulk changes the concentration but does not change the amount of 7-OH consumed. These calculations tell us nothing about whether that dose is effective or safe.

The DEA acknowledges that controlled trials have not established safe consumption limits or standardized dosing for concentrated 7-OH products. Neither DEA nor HHS has determined that below-threshold products are safe.

In a public comment submitted to HHS in July, I urged officials to obtain the human evidence needed to justify a threshold before setting one. Animal studies can reveal hazards, including dependence and respiratory depression, but they cannot, by themselves, identify a scientifically defensible cutoff for human consumption.

Officials may intend these thresholds to distinguish traditional kratom from concentrated products. What evidence shows that crossing that boundary justifies criminal penalties? 

The DEA also owes consumers an accounting of what prohibition could do to them. People seeking relief from pain or withdrawal will still need it after a ban. Some may abandon these products, while others may turn to illicit sellers or switch to other opioids. Criminalizing those choices could make them more dangerous.

Misleading labels, contamination, dependence, and drug interactions warrant attention. Accurate labeling, independent testing, age restrictions, and enforcement against fraud can address several of these concerns. Before resorting to criminal penalties, the DEA should explain why those measures would be inadequate.

We already know how difficult it is to verify a drug's identity, strength, and purity in an illicit market. Creating another prohibited product will give that market another opportunity.

Autonomous adults should be free to decide which substances they consume and which risks they accept. The DEA proposes taking that choice away even as it acknowledges major gaps in the medical evidence. Before the drug police turn more consumers into criminals, they should at least demonstrate how doing so will make those consumers safer.

The post The DEA Wants To Turn 7-OH Consumers Into Criminals appeared first on Reason Magazine.

A Belgian criminal organisation’s links with a Brazilian cocaine gang have been the focus of a major trial in Brussels, where smuggling links have been alleged between European players and the drug cartels of Latin America

In the early hours of 7 September, a convoy of heavily armed police swept through the sleeping streets of central Brussels towards the Haren district, on the city’s north-eastern outskirts. They made their way to 22 Avenue du Bourget, a militarised bunker-like complex that was the former headquarters of Nato.

The modernist complex, with its austere and functional architecture, was hastily built in 1967 and houses the Justitia courtroom, where Belgium’s federal trials are now held. It was here that the perpetrators and accomplices of the 2015 Paris terrorist attacks and the 2016 Brussels attacks were tried in 2022.

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© Composite: Guardian Design/Belga/AFP/Getty Images/AP/Europol

© Composite: Guardian Design/Belga/AFP/Getty Images/AP/Europol

© Composite: Guardian Design/Belga/AFP/Getty Images/AP/Europol

by James Bovard, Activist Post: As the Covid-19 pandemic struck this nation, many Americans were stunned to see top federal health officials brazenly lie to buttress their own power. Bureaucrats and politicians unleashed themselves by shrouding how the feds bankrolled the creation of the pathogen, sanctifying a pseudo-miracle cure vaccine that was concocted almost overnight, […]

When Eric Leas, a public-health scientist, discovered packages of “magic mushroom” gummies for sale in a smoke shop, he wondered: Were these candies even legal? Had they been properly tested, and did anyone actually know what constituted a safe dose? This Aeon piece follows Leas down a rabbit hole as he investigates whether the Amanita muscaria products currently on store shelves are as safe as their candy-like packaging suggests.

I found a product with a very high reported amount of muscimol. It was a gummy product, one in a benign-looking package that did not have childproofing or clear warnings. I began doing the calculation no one wants to do. If a young child ate the entire package, mistaking it for candy, could they die? I took the reported amount of muscimol, the toxicology estimates (the LD50), a conversion used to translate dosing between species, and the average weight of a small child. The result looked bad. Bad enough that I did not quite trust myself. So, I called a friend, Matthieu Rouffet, a medicinal chemist and the dean of science at a local college, who does toxicology calculations more often than I do. I wanted him to tell me I had made an error. Instead, he was alarmed too.

Costa Rica’s Minister of Foreign Affairs, Manuel Tovar, was dismissed from his post last week by the country’s president Laura Fernández. Tovar was considered one of the “heavyweights” of the country’s dominant political faction, having previously served as Minister of Commerce under President Rodrigo Chávez.

The decision was made by Fernández on September 24, because, according to a statement, her foreign minister failed to inform her of an invitation to a meeting held in New York City aimed at strengthening the so-called Shield of the Americas.

Shield of the Americas is a political-military alliance led by Donald Trump that seeks to secure Washington’s geopolitical leadership in the region, and which right-wing and far-right Latin American governments have joined enthusiastically.

Right-wing President Fernández said that failing to report such an important meeting constituted an act of negligence on Tovar’s part. The Costa Rican president also said that Shield of the Americas is a “fundamental platform in the fight against drug trafficking and organized crime.”

The president did not travel to the United States to deliver her speech at the UN General Assembly because she was on an official visit to Colombia with her counterpart, the far-right Abelardo de la Espriella.

The Costa Rican presidency reported that the invitation – which was not extended to her – came from US Secretary of State Marco Rubio himself. Several heads of state from Shield of the Americas member states participated, including Javier Milei of Argentina, José Antonio Kast of Chile, Rodrigo Paz of Bolivia, Daniel Noboa of Ecuador, Irfaan Ali of Guyana, Nasry Asfura of Honduras, Santiago Peña of Paraguay, Luis Abinader of the Dominican Republic, and Keiko Fujimori of Peru, among others.

In this regard, Fernández publicly apologized to the US ambassador to the Central American country, Melinda Hildebrand: “I reiterate to your country my firm and resolute commitment to continue supporting the Shield of the Americas alliance… I regret my absence… The failure to forward that invitation from your government to me did not go unnoticed, and today the foreign minister of the Republic was dismissed,” which clearly demonstrates the enormous importance San José attaches to an invitation from Washington.

Tovar’s dismissal comes on the heels of a series of dismissals of key ministers in Fernández’s government, a development the opposition has used to highlight a certain instability in the very young administration.

“We are concerned about serious foreign policy mistakes that need to be corrected… Second, we are concerned about the stability of the cabinet: in less than five months, five senior officials – including ministers and deputy ministers – have already been dismissed. That instability is not in her best interest, nor in that of her government or Costa Rica,” said the leader of the National Liberation Party caucus.

For his part, the former foreign minister did not explain the reasons behind his decision not to inform Fernández about the invitation. In a post on X, he said briefly: “I thank Laura Fernández for the opportunity to serve the Costa Rican people from the Casa Amarilla, and I wish her every success as President of the Republic for the good of the country. Finally, I would like to commend the team at the Ministry of Foreign Affairs for the passion and dedication with which they undertake every mission on behalf of the country. To them, I offer my eternal gratitude. I accept this moment with great peace of mind. I will always stand by the just causes of the Costa Rican people and the international community.”

The reasons behind Tovar’s decision remain unknown, although several sectors of the opposition have raised suspicions about an alleged ulterior motive on Fernández’s part for not attending the Shield of the Americas meeting – which, if true, could reveal political and diplomatic contradictions deeper than they might appear at first glance.

Duncan is a longtime friend of Max Daly, and a drug addict caught up in “cuckooing,” where dealers take over people’s homes as drug bases in exchange for product. Daly offers a sympathetic portrait of Duncan’s spiralling life, while opening a window onto a bizarre world where the most vulnerable exploit each other—and sometimes even form bonds.

Over the 2000s and 2010s, wave after wave of gangs fanned out from Britain’s drug supply hubs – London, Liverpool and Birmingham – to set up shop in smaller towns and cities across the country. They took over the homes of drug users and young women who had been groomed by older male gang members. As early as 2008 Suffolk constabulary reported that more than a third of Class A drug dealers arrested in Suffolk were under 21, and the majority were from London. (Before this period, most crack and heroin dealers in towns and smaller cities were “user-dealers”, addicted heroin users in their 30s or older, who were not as “professionalised” as the big city drug gangs.) Gangs often used sex workers, who targeted male tenants and moved in, bringing the young dealers with them. Community safety teams, who rescued 80 tenants in London in 2005, were the first to call the tactic “cuckooing”.

Just a few years ago, Jos Leijdekkers was a gangster in Antwerp, working for a major drug lord. Today he’s the most powerful man in Sierra Leone, which he’s single-handedly turned into a crucial port in the transatlantic cocaine trade. European authorities haven’t been able to track him down. Can a journalist? Alexander Clapp details Leijdekkers’s remarkable, violent rise to power, while looking for the man himself:

“These kinds of people, we are always seeing them in Africa. They come, they disappear. But the moment we learned who he was, it freaked me out,” a local car-dealer who was one of the first people to sell a motor to Leijdekkers, told me. “I left Sierra Leone after finding out. I became really scared. Not small scared.” Sophie van Leeuwen, a Dutch correspondent for RTL News, told me she “had the strong feeling I was being followed by the secret police” during the first days of a reporting trip she took to Sierra Leone in February 2025. She was arrested outside a villa where Leijdekkers was believed to reside, informed that she had intruded upon a “special security situation”, and questioned for 15 hours. Her camera and computer were searched and scrubbed. The Flemish owner of her hotel was interrogated over her alleged role in seeding a European spy network in Sierra Leone.

One evening in the hills above Freetown I attended a cocktail party where Western diplomats mingled with aid-workers. “Careful with that,” a European mission head told me when I mentioned why I had come to Africa, swivelling her blue eyes round the room. A Norwegian mining investor assured me that there would only be one way of knowing whether I was making progress in my investigation: “The government will arrange a car crash for you.”

Two skeletons from the Indonesian island of Sulawesi had something strange going on in their mouths. Not cavities. Not the usual wear from a tough diet. Deep, rounded grooves cut into the teeth — a pattern no archaeologist had documented before, and one nobody could explain. The answer, published in Science Advances, pushes the known […]

i have been struggling in the last couple of days to get the facts right and make an update on that horror story of the dead infant found in a deep freezer at an Airbrb apartment in Kypseli district of Athens on August 31. The more I delay to write down and post the update, […]

The post Infant in the freezer stabbed 18 times. Big fail of social services appeared first on Keep Talking Greece.

Mounjaro was first approved by the FDA in 2022 for improving blood sugar control in adults with type 2 diabetes.

The post FDA approves Mounjaro to protect high-risk diabetes patients from heart risks appeared first on BOL News.

The US military has resumed its campaign of bombing alleged drug-trafficking vessels after a two-month pause in a campaign that many legal experts and human rights groups believe constitutes a murder spree.

In a Monday social media post, US Southern Command (SOUTHCOM) said it carried out a “lethal kinetic strike on a low-profile vessel operating along established narco-trafficking routes” in the Pacific Ocean on Sunday. Two people were killed as a result of the attack, SOUTHCOM claimed.

In announcing the strike, SOUTHCOM Commander Gen. Francis Donovan said the attack was part of a campaign of “imposing total systemic friction on narco-terrorists—disrupting their operations, dismantling their leadership, and eliminating cartel terror across the region.”

Donovan’s boasts about the effectiveness of the boat strikes in combating the drug trade come less than a month after a leaked a Drug Enforcement Administration (DEA) analysis revealed that the boat-bombing campaign has not “reduced the amount of cocaine entering” the country, as drug cartels have found alternate methods for shipping their product into the US.

With the latest two casualties, the boat bombing campaign launched nearly a year ago by President Donald Trump’s administration has now claimed the lives of at least 223 people.

Adam Isaacson, director of the Defense Oversight program at the Washington Office on Latin America (WOLA), criticized the administration for resuming its boat bombings despite “overwhelming evidence that they are murder; that many, likely most, of the dead are either super-low-level or uninvolved with drugs; and that cocaine supply is unaffected.”

Brian Finucane, senior adviser to the US Program at the International Crisis Group, delivered a similarly scathing assessment, commenting that “the Trump administration’s lawless killing spree at sea resumes.”

Nicholas Grossman, professor of international relations at the University of Illinois, described the boat strike campaign as “murderous” and “illegal,” adding that its victims are “not terrorists” and “may not even be drug traffickers.”

Investigative journalist Camila Lourdes Galarza observed that “there’s still no proof any of the victims” of the boat strikes were involved in the drug trade.

Lourdes Galarza sarcastically added that if the victims had been drug traffickers, “the US would probably give them a deal” like the one given to Juan Orlando Hernández, the former president of Honduras who was pardoned by Trump last year despite being previously convicted on narcotics trafficking charges.

Kimon de Greef | Longreads | August 4, 2026 | 4,741 words (17 minutes) 

In 1935, two chemists at Tokyo’s Imperial University synthesized a new molecule and unwittingly launched one of the strangest narratives of the psychedelic age. Toshio Hoshino and Kenya Shimodaira were working on a family of compounds known as the tryptamines, which occur widely in nature and have a range of intriguing biological properties. The neurotransmitter serotonin, which among other things regulates mood, cognition, and social behavior, is a tryptamine. So are many psychoactive drugs, although this would only be discovered later on. The Japanese scientists had recently completed the world’s first laboratory synthesis of a molecule called bufotenine, which is produced by toads and certain species of mushrooms. Now, via a sequence of reactions, they engineered a close chemical relative. Diagrams of the two tryptamines looked nearly identical, each represented by two angular rings and a tail, resembling microscopic organisms; the only difference lay in the shape of the head. Such tiny changes in chemical structure “can lead to radically different consequences, like a railroad’s switch points,” as the writer and organic chemist Primo Levi once wrote. The new molecule’s name, following scientific convention, would be 5-MeO-DMT.

Hoshino and Shimodaira published their findings in the Bulletin of the Chemical Society of Japan, leaving no explanation as to why they had conducted these experiments. The early 20th century was a time of wide-ranging exploration in organic chemistry, with researchers synthesizing new compounds to assess their pharmacological potential or better understand the reactions by which one substance could be transformed into another. Many of these compounds had no evident utility, such as 5-MeO-DMT, which for decades was thought only to be a product of the laboratory.

This changed in 1959, when the molecule was isolated from a shrub native to Brazil. Not long afterward, 5-MeO-DMT was detected in Anadenanthera peregrina, a leguminous tree from the Caribbean and South America. For thousands of years, Indigenous communities had been harvesting its slender bean pods to prepare snuffs called cohoba or yopo, which were typically inhaled using hollow bones or bamboo shoots—the earliest known use of psychedelics in the New World. “With this powder they lose consciousness and become like drunken men,” Christopher Columbus observed in the 15th century. The Spaniards regarded such practices as demonic and sought to eradicate them as they colonized the region. After witnessing a yopo ceremony in the Andes, where the snuff was dispensed from a snail shell with a spoon carved from the bone of a puma, one missionary reported, “They summoned the devil.”

The rich biodiversity of the Amazon also yielded other hallucinogenic snuffs containing 5-MeO-DMT. These were prepared from trees in the nutmeg family and were known, in some local communities, as “semen of the sun.” In the early 1950s, a distinguished Harvard scholar named Richard Evans Schultes had documented the snuffs being used for “witchcraft, divination and the diagnosis of illness” by the medicine men of more than half a dozen tribes, describing the effects as “virulently potent.” Schultes expressed incredulity that such a widely used substance had gone unstudied for so long. “It makes one wonder how many more narcotic plants, up to now obscured by better-known ones, still wait to be discovered,” he wrote. These snuffs were only later found to contain 5-MeO-DMT.

A tall, bespectacled man who wore a pith helmet in the jungle, Schultes was considered the father of modern ethnobotany, a field that studies the traditional uses of plants. He was also one of the world’s foremost experts on psychedelic rituals in an era before they had captured mainstream attention. In the 1930s, he had uncovered the ceremonial use of psilocybin mushrooms in southern Mexico and identified the source of an ancient Aztec sacrament as the seeds of a native morning glory vine, which contained a chemical cousin of LSD. He went on to live in the Amazon for a decade, documenting thousands of medicinal plant traditions while researching alternative rubber sources for the US military. The only provisions he carried were instant coffee and tins of Boston baked beans.

Even then, Schultes recognized that incursions from the wider world threatened the survival of Indigenous knowledge. “Time is running out,” he once warned. “The Indians’ botanical knowledge is disappearing even faster than the plants themselves.” Yet capturing this knowledge, as an outsider, was a formidable endeavor. In addition to navigating remote and inhospitable regions, ethnobotanists had to draw on scattered records from disparate disciplines—botany, anthropology, archaeology, plant chemistry, pharmacology, history, geography and sundry other tangential fields of the sciences and arts,” as Schultes put it. There was always the risk that in selecting and piecing together this information one might draw false conclusions.

A misleading narrative about psychedelic toads took hold, involving not only the wrong molecule but the wrong species entirely.

In the 1960s, while Schultes was continuing his ethnobotanical research, 5-MeO-DMT was detected in numerous other plants around the world, including a type of grass that could cause grazing sheep to convulse uncontrollably, a phenomenon known as “staggers.” Then, in 1964, the molecule showed up in an animal for the first time, detected in the skins of Sonoran Desert toads, a species that had formerly been of interest only to the occasional herpetologist. This breakthrough was thanks to an Italian chemist named Vittorio Erspamer. Earlier in his career, Erspamer had discovered the neurotransmitter serotonin—a pivotal moment in the field of neuroscience, laying the groundwork for understanding chemical signaling in the brain. His lifelong interest was pharmacognosy, or the study of drugs from natural sources; by the end of his career, he would identify and name more than 60 new compounds, including from octopuses, shellfish, and sea anemones, and twice be nominated for the Nobel Prize. “Land and sea are populated by a miraculous variety of creatures, representing the outcome of the tremendous biosynthetic work carried out by Nature over hundreds of millions of years,” he once wrote.

No animals captured his attention like amphibians, which he described as “an inexhaustible mine of active compounds.” In his laboratory, which was decorated with pictures of frogs and toads, Erspamer and his assistants minced the skins of different species with scissors and exposed them to a variety of tests: gas and paper chromatography, X-ray fluorescence analysis. Colleagues from around the world sent him samples by airmail, and in the early 1960s he received 21 Sonoran Desert toad specimens that had been skinned and dried in Arizona. (At the time, the species was classified as Bufa alvarius, a name that remains in widespread use despite being formally changed in 2006.) The findings were striking. All toads produce bufotenine, but this was the only species among some of the most chemically diverse animals in the world that contained 5-MeO-DMT.

Erspamer’s study was published in a technical journal in 1965, just as the psychedelic revolution was getting started. At around this time, a small cohort of psychonauts began using synthetic 5-MeO-DMT, alerted by its discovery in South American snuffs, but it would be decades before anyone in this milieu realized that the same molecule could be obtained from a North American toad. Knowledge of psychedelic toads was fractured across niche academic disciplines, and even Erspamer appears not to have been aware that 5-MeO-DMT had hallucinogenic properties. But over the next two decades, something remarkable happened: A misleading narrative about psychedelic toads took hold, involving not only the wrong molecule but the wrong species entirely. Although 5-MeO-DMT can produce experiences of overwhelming intensity, often interpreted as encounters with ultimate truth, the history of toad smoking is riddled with false leads and misinformation.

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In 1956, a psychiatrist named Howard Fabing co-authored a study in Science, the prestigious academic journal, about the effects of a purported hallucinogen. Like many others in his field, he had become fascinated by drugs that appeared to evoke states of psychosis, inspired by the discovery, the previous decade, of LSD. People had reported overpowering hallucinations after consuming tiny doses of acid, as the substance would become known in psychedelic culture. “My field of vision fluctuated and swam like an image in a distorted mirror,” its creator, a Swiss chemist named Albert Hofmann, recalled of his first trip (during which he somehow wobbled home from work on his bicycle). Accounts like these, Fabing wrote, had “precipitated the whole field of biochemistry into a new look at the brain.” Psychoanalysis had long been the dominant paradigm for treating mental illness, but now another possibility was arising. If certain compounds could seemingly induce the symptoms of insanity, then perhaps insanity was a result of faulty brain chemistry—and could thus be treated with psychiatric drugs.

Fabing’s interest lay in using psychedelics not as therapeutic agents but as tools for understanding how a healthy mind could malfunction. This was seen as especially urgent in the 1950s, when around half the hospital beds in the developed world were occupied by patients with schizophrenia and other mental disorders. “The stakes are high,” Fabing wrote. Scientists had begun revisiting anthropological accounts of hallucinogenic rituals—iboga ceremonies in Central Africa, peyote cults in the American Southwest. The term “psychedelics” was not yet in use; instead, such substances were known as psychotomimetics, reflecting an underlying belief that they induced not illumination but madness. Intriguingly, many of them shared a chemical structure with serotonin.

This line of inquiry had led Fabing to bufotenine, the tryptamine relative of 5-MeO-DMT that Hoshino and Shimodaira had originally synthesized. Besides occurring in most toad species, bufotenine was known to occur in fly agaric mushrooms, the iconic red toadstools of fairy tales, and thought to be the origin of the Norse berserker legend, involving warriors who reputedly consumed the mushrooms and entered such frenzied states that they were invincible in battle—the root of the phrase “going berserk.” Separate accounts from Siberia described nomadic herders using fly agaric in shamanic ceremonies, taking pains to prolong its psychoactive effects. “The urine of persons intoxicated with fly agaric is not wasted,” an anthropologist noted in 1901. “The drunkard himself drinks it to prolong his hallucinations, or he offers it to others as a treat.”

Fabing hypothesized that schizophrenia might arise from the abnormal production of bufotenine in the brain, possibly instead of serotonin. To explore the compound’s effects in more controlled settings, he and a colleague injected subjects with escalating doses and monitored their reactions. One man experienced a bodily numbness that he described as “a pleasant Martini feeling.” Another became light-headed and reported visual hallucinations. “I see white straight lines with a black background. I can’t trace a pattern,” he exclaimed. “Now there are red, green, and yellow dots, very bright, like they were made out of fluorescent cloth, moving like blood cells through capillaries, weaving in and out of the white lines.” Based on the results of this experiment, the scientists concluded that bufotenine had hallucinogenic properties similar to LSD.

This finding, published in a reputed journal, would later cross disciplinary lines and be picked up in the rush to solve a major anthropological mystery. Across Mesoamerica, archaeologists had unearthed a preponderance of toad artifacts, including detailed depictions of the parotid glands (located at the top of the neck) in which toads produce their defense toxins. Each of the great civilizations—the Olmecs, the Mayans, the Aztecs—had left behind extensive toad artworks: sculptures, altars, friezes, ceramics. There were middens of toad bones in what appeared to be ritual contexts, sometimes comprising thousands of skeletons. What significance had these ancient societies ascribed to toads?

Women in ancient Rome used toad secretions to murder their husbands; 16th-century Italian chemists laced salts with toad toxins for poisoning the food of enemies.

In the 1970s, amid surging popular interest in psychedelics, a compelling academic theory arose: that toads had been used as ritual intoxicants, much like psilocybin mushrooms or ayahuasca. It was well established that Indigenous cultures across the region had performed healing or shamanic rituals with psychedelics. Of the psychoactive plants identified worldwide, close to 90 percent were native to the Americas, with more than a dozen psychedelic traditions documented in Mexico alone. Fabing’s research had suggested that bufotenine, which occurs in many species of toads, was hallucinogenic. The pieces of the puzzle all seemed to connect.

There was also an obvious candidate species: Bufa marinus, more commonly known as the cane toad, a lumbering, fleshy creature that can grow up to ten inches in length and weigh as much as six pounds, a little less than a typical newborn baby. Cane toads were native to Central America, dwelling in marshlands and swamps. They corresponded to many of the archaeological depictions of toads, with bulging parotid glands, and their bones were frequently excavated during archaeological digs. It wasn’t long before researchers were confidently asserting that there had been a psychedelic cane toad tradition in Mesoamerica. “The Olmecs had a predisposition for consuming toads,” one scholar wrote in a book about the region’s archaeology. “Consumption of these toads produces hallucinations.”

Yet the theory had a glaring weakness. In addition to bufotenine, the cane toad produces an array of other chemicals, several of them acutely toxic. Its glands secrete two classes of compounds, bufogenin and bufotoxin, that can be lethal to humans even in tiny doses. Similar molecules are found in the skins of many toad species around the world and have long been used for preparing poisons. Women in ancient Rome used toad secretions to murder their husbands; 16th-century Italian chemists laced salts with toad toxins for poisoning the food of enemies. At English country fairs in the 17th and 18th centuries, charlatan doctors hawked medicines by feeding live toads to hired assistants, who fainted or became delirious in front of onlookers, only to revive upon swallowing whichever concoction was being advertised. The assistants survived by lining their mouths and stomachs with oil or by consuming large meals in advance. They became known as “toadies,” a word that has drifted from being associated with charlatanism to its modern definition: a sycophant or obsequious helper.*

The driving question for proponents of the psychedelic cane toad hypothesis thus became how precolonial Mesoamerican cultures might have isolated bufotenine from these deadlier defense toxins. In the early 1970s, an American graduate student named Timothy Knab went searching the Mexican countryside for a healer, or curandero, who could provide an answer. Knab eventually came across an elderly man in the mountains of Veracruz who claimed to remember a potion that had not been used in decades. The man ground the glands of 10 cane toads into a paste, added lime water and ash, then boiled the mixture overnight. This was stirred into corn beer, filtered, mixed with cornmeal, and left for several days to ferment before being heated to drive off the remaining moisture. The result was a hardened doughlike substance. The curandero refused to consume it and only reluctantly consented to dose Knab, who recorded the experience in dissociative terms. “Profuse sweating is noted along with a sudden increase in heartbeat,” he wrote. “The heartbeat becomes continuously harder and stronger. A pronounced chill sets in with twitching of the facial and eye muscles. A pounding headache and delirium shortly follow the onset of twitching.” For several hours, he lay in front of a fire, sweating and unable to move.

In a seeming blow to the theory, Knab reported no hallucinations from this experiment. But his account, which he presented at an anthropology conference in Mexico City, stirred the imagination of another young scholar. Alison Kennedy was the heiress of a wealthy Palo Alto family who would later adopt the alter ego Queen Mu and launch an influential cyberculture magazine called Mondo 2000, a futuristic mash-up of technology, psychedelics, and arts writing. Before all of this, Kennedy was an anthropology graduate student with an interest in Mesoamerican iconography; this had led her, almost inevitably, to the question of toads. She turned her eye to the artifacts of the Olmecs, who died out around twenty-five hundred years ago and are considered the first major civilization in Mesoamerica. Jaguars featured prominently among their artworks, which many researchers had interpreted as a sign of mythological significance. But Kennedy concluded that this had been a case of mistaken identity. Many of the artworks weren’t jaguars, she argued. They were toads.

In support, she presented dozens of illustrations, focusing on what she described as “the attributes of toadiness”: downturned mouths, inward-facing forelimbs, glandular swellings. She became drawn, like so many others in her field, to the idea that toads had been used in psychedelic ceremonies.

To account for the toxicity of the toads, Kennedy proposed a solution that reads like science fiction from the magazine she later founded. In addition to toads, the Olmecs had left behind depictions of many other animals, including ducks, which have highly efficient livers. Perhaps ducks had been used as bio-processors, feeding on toads and metabolizing their poisonous compounds so that humans could safely consume them. Kennedy drew attention to Olmec figurines of people wearing what appeared to be duck-billed masks. These masks would have provided protection from “venom spatters” as putative toad shamans “stood at their toad altars lancing the parotid glands,” she posited. This relied on the assumption that ducks could eat toads without being poisoned themselves. To investigate further, Kennedy visited a zoo in Texas, where she and the head aviculturist flung some cane toads into a duck pond. The ducks had been reared in captivity and were “toad-naive,” as Kennedy wrote, yet they pursued the toads with avidity, juggling their soft bodies before gulping them down. Kennedy described this behavior as “singular and apparently wholly instinctive.” Duck bills have neither nerve endings for sensing toad toxins nor blood vessels for absorbing them; the juggling movements were conceivably an adaptation for rinsing poisons into the water. Two of the duck species in the pond happened to be native to Mexico, home of both the Olmec culture and Bufa marinus. Here, at least, was proof that ducks had an appetite for the toads.

Now Kennedy took her suppositions even further, reexamining the literature on a famous Olmec site where thousands of toad skeletons had been excavated. The ruins featured an elaborate system of water channels hewn from some three hundred tons of rock, running between a sculpture of a jaguar (or possibly a toad) and an enormous stone receptacle in the shape of a duck. The main channel drained into a series of smaller pools too shallow for human bathing; confounded researchers had guessed that they were for unspecified “ritual use.” With a flourish, Kennedy now presented her final claim: That this complex hydraulic system had been designed as an integrated bufo-culture station, including both spawning grounds for toads and a captive population of bio-processing ducks. These bold ideas won her a prize at an anthropology conference in 1979, but there was one problem: No one had taken the obvious next step and tested whether the duck livers were in fact hallucinogenic. For all the scholarly attention it had garnered, the mystery of the psychedelic toad remained unresolved.

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In the early 1980s, after reading about Fabing’s bufotenine study, a British artist named Adrian Morgan began a series of personal experiments with toads. These included “licking poison glands, rubbing animals against my forehead, and in one instance collecting venom with blotting paper . . . and then eating the paper,” he reported. Disappointingly, Morgan experienced no hallucinations from these tests, which seemed only to aggravate his research subjects. “One specimen of green toad showed its disgust by leaping from an open window into the celery patch below me,” he wrote. “It was never seen again.”

One spring, Morgan visited a forest outside London and came upon two dead female toads in a pond. He took them home, where he pounded their skins and poison glands in a mortar. Then he snuffed the residue and took notes in an increasingly jagged hand:

3:41 p.m. First quantity ingested into right nostril. Within one minute, nostril strongly anesthetized.

3:49 Sneezing violently, profuse sweating of forehead.

4:03 Fleeting pain at temples.

4:05 Salivating strongly.

4:15 Thick saliva at back of throat causing tendency to gag.

4:32 Feeling very tired.

Midway through, colors briefly appeared richer and moving objects left trails in his vision, like speed blurs. Morgan described these sensations as “only slightly psychedelic” and concluded, “The experience was not pleasant.”

Yet the notion of hallucinogenic toads persisted, cropping up in stranger contexts still. While Morgan was pursuing his investigations, stories of psychedelic cane toad use began surfacing in Australia, of all places, where the animals had been introduced in the 1930s to control pests on plantations. The toads had gone rogue, consuming native frogs, birds, insects, small marsupials, even Ping-Pong balls and cigarette butts flicked toward them at pubs—almost everything except the swarms of sugarcane beetles they had been imported to feed on. Australia’s plague of beetles had been compounded by a plague of toads. 

This was possible in large part because toads are opportunistic and superbly adaptable creatures. They are residents of the gutter, the verge, the ditch. They can hunker down when times are bad and burst to life when conditions favor them. They are capable of producing millions of eggs. In their present form, toads have existed for at least 30 million years, enduring all kinds of planetary upheaval, from ice ages to the rise of humans. Released onto a new continent, the cane toads marauded unstoppably.

For all the scholarly attention it had garnered, the mystery of the psychedelic toad remained unresolved.

In the 1980s, 50 years into the invasion, an Australian filmmaker named Mark Lewis began working on a satirical documentary, Cane Toads: An Unnatural History, which Werner Herzog later declared to be his favorite film of all time. Hundreds of millions of the animals had taken up residence across Australia’s east coast, expanding their occupied range at a rate of more than 15 miles annually. Researchers dubbed the toads “an amphibian weed.” Streets were slicked with flattened toad carcasses, which emitted a fishy aroma. Bands of vigilantes went after the animals with cricket bats or swerved deliberately to run them over, but the toads continued their relentless spread.

During his research for the film, Lewis picked up on a rumor that people were getting high on the toads. He ended up speaking by phone with a man who claimed to have been in prison, where the inmates “would race to grab a toad if it found its way inside the compound,” Lewis told me. His source was unwilling to appear on camera, so Lewis hired an actor to deliver the lines. “You use a little quantity at first, then larger,” the man mumbles in the film, which identifies him as a “cane toad drug abuser” from the town of Mullumbimby. He makes a reference to Carlos Castaneda’s writings, saying how users of peyote would “see the world through the consciousness of the cactus. “With a weak laugh, the man adds, “The toad’s the same.”

The documentary also features a detective from Queensland who attests that people in “hippie communes” have been tripping on cane toads since at least the 1970s. “When heroin and other drugs weren’t freely available, the next best alternative was to go out and get a cane toad, “the detective explains. These toads would be boiled down in billycans to produce a sludgy brew, which the hippies purportedly drank. “From what I’ve been told, they had fantastic color hallucinations, “the detective says. “It warped their sense of time.”

Australians have a certain reputation for toughness, but even the hardiest among them would likely have been poisoned by the bufotoxins in this recipe. Yet Lewis also heard about a more plausible mode of ingestion. A local narcotics squad was said to possess a jar of confiscated dried cane toad skins that could be “shredded and put into a hookah or a pipe and smoked,” apparently causing intense hallucinatory effects. At one point during his research (“to see what all the fuss was about”) Lewis rolled a small quantity with tobacco into a joint. “I smoked it, and the only result was that I got a bad headache,” he told me. “I would not recommend that kids try this at home.”

Dubiously sourced accounts followed of Australians who died after drinking toad tea and a man supposedly being imprisoned in South America on toad-licking charges.

But in 1988, the year Lewis’s film came out, a moral panic began that swept the concept of psychedelic toads into popular culture. “I feel partly responsible,” Lewis told me decades later, sounding mystified. This strange sequence began with media reports in the United States of Australian hippies “forsaking traditional drugs for cane toads, which they boil for a slimy, potentially lethal cocktail.” Later that year, a doctor at the Haight Ashbury Free Clinic, a San Francisco drug treatment facility established during the Summer of Love, jokingly mentioned the “rare 1960s practice of toad licking” during a lecture. Afterward, the clinic was inundated with calls from reporters around the world, wanting to know about “crazed hippies licking toads in the mountains,” as the clinic’s director later recalled. Staff assured the journalists that there was no evidence of toads being licked in the United States, but the idea, like some invasive animal, took on a life of its own. At a conference on crack cocaine the following year, the Berkeley police chief announced that toad licking was a “problem that comes up from time to time.” An official from the Drug Enforcement Administration was quoted saying that cane toad secretions were “in the same (legal) category as heroin or LSD.” Bufotenine had indeed been listed as a Schedule I substance in 1967—even though, at the time, there had been virtually no reports of anybody using it. Citing the DEA, news articles now declared toad licking “the latest way to hallucinate.” (One headline: ”A Desperation High: Crack? Coke? Croak!”) The DEA official later clarified that he had said nothing about toad licking, but the phrase continued spawning fresh rounds of coverage until, as Scientific American later put it, “reality imitated fiction.”

In 1989, two teenagers were hospitalized in New Mexico after licking toads, which they had read about in the papers. The following year, two men were admitted to an emergency ward in Canada, bewildered and vomiting, after reportedly scraping the back of a pet cane toad and eating its secretions on crackers; the tabloids later claimed that one of the men had committed suicide after being discharged. Dubiously sourced accounts followed of Australians who died after drinking toad tea and a man supposedly being imprisoned in South America on toad-licking charges. Hungry for copy, journalists pressed experts for comment. “It gives them a kick like alcohol,” an Australian herpetologist professed, of the toad users. In a foretelling of toad mythmaking to come, it had become difficult to tell fact, conjecture, and fabrication apart. “This is a case of media feeding on media,” a reporter who covered the story would later reflect. Psychedelic toads, as a 1993 journal article titled “Misuse and Legend in the ‘Toad Licking’ Phenomenon” described it, had become an “informational epidemic.”

Meanwhile, the television drama L.A. Law ran an episode involving a retiree accused of toad licking, and Beavis and Butt-Head licked toads on MTV. (“Tastes like chicken,” Beavis remarked.) Psychedelic toads also captured the attention of lawmakers: A state representative in Georgia cautioned his colleagues about “the extreme dangers of toad licking,” while a representative in South Carolina proposed sentencing offenders to community service at zoos. The men appear to have been speaking in jest, but Canadian police were serious when, in 1991, they urged officials to ban imports of cane toads and outlaw them as pets, citing “the deaths of several Australian drug users.” Before long, Australia also passed laws against psychoactive toad use, listing bufotenine as a controlled substance. Toad licking had become so ingrained in popular consciousness that three decades later, while I was working on this book, people continuously brought it up as a point of reference. Yet the hype about cane toads obscured a crucial detail. As the anthropologist Wade Davis, who became drawn into solving the mystery, would later write, “An animal venom that contained no hallucinogenic agent but that did contain lethal poisons was not likely to inspire a new drug craze.” A satirical film had broadcast rumors that snowballed into full-blown hysteria about cane toads, but there was still no evidence that they were psychoactive at all.

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Kimon de Greef is a journalist from South Africa and the author of The Ego Trip, an investigative nonfiction book about psychedelic toads. His work has appeared in The New Yorker, New York, The New York Times, The Guardian, Guernica, National Geographic, and other publications. He has coauthored a book about abalone poaching and holds a conservation biology master’s from the University of Cape Town.