• Strauss Zelnick, the CEO of Take-Two Interactive, said he prefers working out to playing video games.
• He is a longevity buff, deep into fitness and anti-aging habits.
• In a candid conversation with Business Insider, he said skip the peptides, and try these 7 things instead.

Media mogul Strauss Zelnick spends his days hyper-focused on making the most creative, innovative, best video games in the world.

As the CEO and Chairman of video game-maker Take-Two Interactive, he's readying to release Grand Theft Auto 6 next month.

At home though, he doesn't play games. He prefers to spend his time working out and staying healthy for a long time.

At Business Insider's "The Long Play" event on Thursday, Zelnick said his formula for healthy aging is both simple and effective.

While he calls biohacker Bryan Johnson, the man behind the "Don't Die" movement, a friend, he said trying to live forever is a pretty silly strategy.

"There's almost no evidence that anything anyone is doing will increase your lifespan," he told Business Insider's Senior Leadership & Workplace Correspondent, Sarah Needleman. "How many of us really want to increase our lifespan from like 96 to 101? Look, that is not on my bucket list, thank you very much."

Instead, Zelnick, who wrote a book on "Becoming Ageless" in 2018, focuses on the same core behaviors for "taking care of yourself" that longevity experts around the world swear by for maintaining health and happiness for the long haul.

1: Do not smoke

"Smoking is the factor most highly correlated with a short, unhealthy, and frankly, unhappy life," Zelnick said. "Don't smoke."

2: Don't abuse alcohol and drugs

These lead to "a bad old age, or no old age," he said.

3: Get some exercise

Zelnick said: "You don't have to do what I do," with 6 a.m. wakeup calls for group training sessions, or twice-a-day workouts.

"I do what I do because I love it, it's my passion," he said. "If you walk 30 minutes a day, four or five days a week — just walk — you're like 80% of the way there."

4: Eat a "responsible" diet

Zelnick says he doesn't have an "insanely healthy diet," but he tries to maintain some balance. "I eat a lot of vegetables and salads and protein — I also like sweets, and I do eat carbs."

5: Sleep at least 7 hours a day

Zelnick says he treats this as a non-negotiable for his business.

"If you're getting less than six hours, you're making bad decisions," he said.

6: Have "some kind of emotional or spiritual life"

Longevity experts stress this is key for mental health, and establishing a sense of purpose in the world.

7: Find community

Zelnick said it's critical to get support from "people who love you."

8: Skip overhyped health hacks

Zelnick says don't waste your time with all the overhyped, unproven health hacks.

"All the other stuff, like, peptides? A: No," he said. "We have an FDA for a reason. Don't take something that is not double-blind tested."

And, he said, be careful with some of the internet's most famous longevity gurus. He name-checked controversial Harvard professor David Sinclair, who has made bold promises about the anti-aging effects of unproven supplements, including resveratrol, a plant polyphenol found in grapes and red wine, and NMN, which is a precursor to NAD, the vital coenzyme that's in every cell of our body.

"A medical doctor actually is a degree: M-D, an MD degree," Zelnick said. "Not a David Sinclair degree, he is not actually a doctor."

House Speaker Mike Johnson, R-La., rejected a question from CNN chief congressional correspondent Manu Raju about seating newly elected Democrats as a "nonsense narrative."

While campaigning in Iowa for Republican Rep. Zach Nunn, whose seat is among those that Democrats are targeting ahead of next week's midterm elections, Johnson fielded questions from Raju about President Donald Trump and the GOP's political strategy during the elections and beyond.

"Will you vow to seat every Democrat who wins on Jan. 3?" Raju asked, referring to the day elected members will be sworn in.

"Of course, this is a nonsense narrative," Johnson replied. "We are going to follow the law."

THUNE WEIGHS NIGHTMARE SCENARIO FOR GOP AS DEMOCRATS THREATEN TO FLIP HOUSE

"What if Trump says ‘it's a rigged election’?" Raju asked.

"Look, I'm a constitutional attorney. I've always been steady and consistent about this. This is going to be a no-drama swearing-in ceremony, but we're going to hold the majority, and I'm going to be the speaker of the House," Johnson said. "And when I administer the oath, there will be one on Jan. 3. We'll administer the oath to everybody."

Raju pressed Johnson, "If Trump says 'Don't seat them,' you'll resist, then?"

"I'll do my job as the speaker of the House," Johnson replied. "The president has vowed, of course, he wants to follow the law as well. That's what's going to happen."

Johnson also defended Trump’s involvement in midterm races, saying he is having "no drag at all" on Republicans’ chances.

NEWSOM SPARS WITH TRUMP-APPOINTED PROSECUTOR OVER 20,000 SUSPECTED NONCITIZENS ON VOTER ROLLS

SPEAKER JOHNSON PREDICTS DEMOCRATS' FAR-LEFT SHIFT WILL ‘JUICE ENTHUSIASM’ FOR GOP IN MIDTERMS

"I’ve seen the voters on the ground, and I’m telling you the polls are wrong, they are inaccurate, they’re underrepresenting Republicans and many of the pollsters have admitted that," he said. "The polling isn’t accurate, the Republicans aren’t responding anymore."

Raju challenged that assessment, questioning why Republicans were spending heavily in traditionally Republican districts.

"You're spending millions in deep Republican districts," Raju said.

Johnson responded that Iowa is a state where Republicans "always win, but it's close" and said battleground districts exist across the country, particularly following recent redistricting efforts.

"We have to win in the districts that are presented, and we’re leaving everything on the field to get it done," he said.

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Mary Marslender, a GOP consultant and former senior advisor to the U.S. Senate, criticized Raju's questioning in comments to Fox News Digital.

"CNN is once again pushing a fake narrative — color me shocked. Instead of chasing a nonexistent 'Trump won’t seat Democrats' story, Manu Raju should focus on reporting the news that matters," Marslender said. "Americans are concerned about costs, wages, the border, and crime. If reporters covered those real issues, perhaps their audiences wouldn’t keep shrinking. Speaker Johnson’s answers were consistent with both the law and standard House procedure. Raju’s repeated hypotheticals reveal more about the story CNN wants to tell than any actual plan to block lawmakers."

Fox News Digital reached out to Johnson's office and CNN for additional comment but did not immediately receive responses.

En el autobús: alguien pulsa el botón de la parada y deja ver unos hoyuelos en las uñas. En el trabajo: las descamaciones del cuero cabelludo se vierten sobre el teclado. En el gimnasio: el pantalón corto muestra unas placas rojas en las rodillas. Es psoriasis, es la psoriasis que se ve, “esa persona tiene psoriasis”, se dirá. Sí. Pero es solo la manifestación visible de esta enfermedad inflamatoria inmunomediada (IMID). La psoriasis se mete en la cabeza, puede afectar psicológicamente a quien la padece, y llega la falta de autoestima, aparece la ansiedad, incluso la depresión. O se desencadena la artritis psoriásica, una dolencia que ataca las articulaciones, los tendones y la columna, y que sufren entre el 20% y el 30% de los pacientes. Sobrepeso, también, un 30% lo tienen. Y diabetes. Hipertensión. Enfermedades intestinales, oculares.

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• People magazine has awarded 38 men the coveted title of Sexiest Man Alive.
• Mel Gibson was the first to receive the title in 1985. Noah Wyle currently holds the crown.
• Brad Pitt, George Clooney, Johnny Depp, and Richard Gere have each been selected twice.

Noah Wyle has been named the Sexiest Man Alive by People magazine.

People published its inaugural Sexiest Man Alive issue in 1985. Since then, 38 different men have received the title, with four of them being named Sexiest Man Alive twice.

The vast majority of the men on this list are white actors; only five men of color have been selected for People's famous cover. They're joined by a few musicians, one star athlete, and one Kennedy.

Continue reading for a list of every man who's received the title, listed in reverse chronological order.

2026: Noah Wyle

Noah Wyle rose to fame as Dr. John Carter in NBC's medical drama "ER," alongside former Sexiest Man Alive cover star George Clooney.

Wyle was nominated for outstanding supporting actor in a drama series at the Emmys several times in the 1990s, though he never won.

Two decades later, Wyle returned to the world of medical dramas as Dr. Michael "Robby" Robinavitch in HBO Max's "The Pitt" — and finally won his first Emmy for outstanding lead actor in 2025. He also won for outstanding drama series as an executive producer.

Wyle, 55, continued his winning streak into 2026, taking home a second consecutive best actor Emmy and the title of Sexiest Man Alive.

"You get into this because you are a natural observer. Then that privacy is immediately taken from you if you get any notoriety," Wyle told People of his acting career. "It could be a hard thing to reconcile. It took me a long time. 'The Pitt' gives me the opportunity to do it differently than I did the first time — with a little bit more presence and a little bit more composure."

2025: Jonathan Bailey

Jonathan Bailey was an award-winning theater actor when he rose to global stardom as Lord Anthony in Netflix's Regency romance series "Bridgerton."

Bailey has since received an Emmy nomination for his role in the Showtime series "Fellow Travelers," made his big-screen debut in the 2024 musical hit "Wicked," and landed a leading role in the 2025 summer blockbuster "Jurassic World: Rebirth."

Bailey received the Sexiest Man Alive title ahead of the premiere of "Wicked: For Good," in which he reprises his role as Prince Fiyero. He is the first out gay man to grace People's most famous cover.

"It's a huge honor. Obviously, I'm incredibly flattered. And it's completely absurd," Bailey told People.

"When I was really young, I was very confident about who I was, and maybe I lost that as I grew up," he continued. "We're all sort of trying to get back to the origin, aren't we? But I was swimming in the sea about an hour ago with a good gang, and I felt all right in my skin."

2024: John Krasinski

John Krasinski rose to prominence as Jim Halpert on NBC's hit sitcom "The Office," which wrapped its nine-season run in 2013.

Three years later, Krasinski transitioned from supporting roles in rom-coms like "It's Complicated" and "Something Borrowed" to the leading man in Amazon's action series "Jack Ryan."

Krasinski also made his name as a director with 2018's "A Quiet Place," in which he co-starred with his real-life wife, Emily Blunt. The horror movie's rare box-office success led to a sequel in 2020 and a prequel in 2024 starring Lupita Nyong'o.

"I had to pitch the studio like 54 times before they said yes," Krasinski told People. "I'm pretty sure someone said, 'Sorry, is Jim from 'The Office' going to direct this?' And I went, 'Oh, it's John, but we'll get there.'"

2023: Patrick Dempsey

Patrick Dempsey starred as Derek Shepherd, aka "McDreamy," for 11 seasons on "Grey's Anatomy." The role drew a passionate following, including many supporters of his character's will-they-won't-they relationship with Meredith Grey, played by Ellen Pompeo.

Although Dempsey had been featured in People's Sexiest Man Alive issue several times before, he didn't take the crown until 2023, eight years after he left the hit show.

"I'm glad it's happening at this point in my life," he told People of the honor. "It's nice to have the recognition, and certainly my ego takes a little bump, but it gives me the platform to use it for something positive."

The actor founded The Dempsey Center to make comprehensive cancer treatment more accessible. He has also starred in beloved movies like "Sweet Home Alabama," "Enchanted," and its 2022 sequel "Disenchanted."

2022: Chris Evans

Chris Evans is best known for playing Captain America in the MCU, although he officially hung up his shield following "Avengers: Endgame" in 2019.

He has also starred in celebrated films like "Scott Pilgrim vs. the World," "Snowpiercer," and "Knives Out."

"This whole thing is tough to be interviewed about. It feels like a weird form of humble bragging," Evans told People of the honor.

"My mom will be so happy," he added. "She's proud of everything I do but this is something she can really brag about."

2021: Paul Rudd

Paul Rudd's breakthrough role came in 1995, starring opposite Alicia Silverstone in the popular coming-of-age drama "Clueless."

He rose through Hollywood primarily as a comedic actor, starring in films like "Wet Hot American Summer," "Knocked Up," and "Anchorman." He also portrayed prominent recurring characters in beloved TV shows "Friends" and "Parks and Recreation."

More recently, Rudd is widely known for his role as Ant-Man in the MCU, as well as the critically acclaimed Netflix original series "Living With Yourself."

The 52-year-old actor said his wife was "stupefied" when he received People's coveted crown.

"I'm hoping now that I'll finally be invited to some of those sexy dinners with Clooney and Pitt and B Jordan," he told the magazine. "And I figure I'll be on a lot more yachts. I'm excited to expand my yachting life."

He continued: "And I'll probably try to get better at brooding in really soft light. I like to ponder. I think this is going to help me become more inward and mysterious. And I'm looking forward to that."

2020: Michael B. Jordan

Michael B. Jordan is the fifth man of color to receive People's honor.

He first rose to fame playing quarterback Vince Howard on NBC's "Friday Night Lights," but his Hollywood breakthrough came in 2013, when he starred in Ryan Coogler's directorial debut, "Fruitvale Station."

That same year, at the age of 26, he was featured in People's first annual Ones to Watch portfolio. 

He has since starred in major blockbuster films, including the 2015 "Rocky" sequel "Creed" and the MCU's 2018 masterpiece "Black Panther."

Jordan has also made a name for himself as a passionate activist for racial equality, marching in Black Lives Matter protests during the summer of 2020.

At 33, he described his Sexiest Man Alive title as "a cool feeling."

"When my grandmother was alive, it was something that she collected, and then my mom naturally reads it a lot and my aunts as well," he told People. "This is one that they're definitely going to have a special place for."

2019: John Legend

John Legend is only the fourth man of color to be chosen and the third-ever musician — all three of whom have starred as coaches on NBC's "The Voice."

At the time of his crowning, the "All Of Me" singer had released five critically acclaimed R&B albums, two of which had been certified platinum. His Sexiest Man Alive title came shortly after the release of "A Legendary Christmas Deluxe," the deluxe edition of his sixth studio album and first Christmas album.

Legend's wife, Chrissy Teigen, had an extremely on-brand reaction to her husband's announcement: "all downhill from here," she tweeted.

"She's proud of me," Legend told his fellow coaches on "The Voice." "You know, she makes fun of me almost all the time, but she hasn't even been snarky about this. She's like legit proud of me. I finally impressed my wife!"

2018: Idris Elba

Idris Elba became the third man of color to be given the honor. He rose to fame for his role as Baltimore drug kingpin Stringer Bell on HBO's "The Wire" in the early 2000s.

The actor also appeared in multiple Marvel Cinematic Universe films as the keeper of the Asgardian bridge, Heimdall. There has even been a fan-fueled campaign to crown him as the next James Bond.

"I was like, 'Come on, no way. Really?'" Elba told People about being named Sexiest Man Alive. "Looked in the mirror, I checked myself out. I was like, 'Yeah, you are kind of sexy today.' But to be honest, it was just a nice feeling. It was a nice surprise — an ego boost for sure."

2017: Blake Shelton

Blake Shelton is the second musician ever to be given People's highest honor.

Shelton's selection, however, did not go over well.

One person quipped: "I don't think he's even the sexiest man named Blake Shelton."

Still, Shelton's love life hasn't seemed to suffer since he received the Sexiest Man moniker. He and singer Gwen Stefani wed in 2021.

2016: Dwayne "The Rock" Johnson

Former professional wrestler and current actor Dwayne Johnson became the second man of color to be named Sexiest Man Alive after his celebrated voiceover role in Disney's "Moana."

When he heard of his Sexiest Man title, he told People, "I said, 'That's awesome.' And then what went through my mind was just how cool and exciting it is. And then I thought, 'Wow, we've pretty much reached the pinnacle.' I'm not quite too sure where we go from here. I've done it all, this is it."

2015: David Beckham

Despite being the first and only athlete to be honored with the annual cover, David Beckham told People, "I never feel that I'm an attractive, sexy person."

Beckham's wife, former Spice Girl Victoria Beckham, would likely disagree. 

In 2019, the couple's son, Brooklyn Beckham, was also featured in People's Sexiest Man Alive issue. 

2014: Chris Hemsworth

Chris Hemsworth has stolen hearts as Thor throughout Marvel's "The Avengers" franchise, which made him a natural pick for 2014's Sexiest Man Alive after "Thor: The Dark World" hit theaters the year before.

2013: Adam Levine

Maroon 5 frontman Adam Levine became the first musician and second non-actor — out of only five total — to grace People's Sexiest Man Alive cover.

Levine made headlines in 2022 after Instagram model Sumner Stroh came forward and said that she'd had an affair with the singer. Stroh said that Levine, in fact, had asked her if he could name his next child with wife Behati Prinsloo "Sumner." 

Levine denied having an affair with Stroh but admitted that he had "crossed the line." 

Prinsloo and Levine welcomed their third child in January 2023. 

2012: Channing Tatum

Channing Tatum nabbed the cover after his star-making turns in "Magic Mike," "The Vow," and "21 Jump Street."

2011: Bradley Cooper

"I think it's really cool that a guy who doesn't look like a model can have this," Bradley Cooper told People after being named Sexiest Man Alive.

"I think I'm a decent-looking guy. Sometimes I can look great, and other times I look horrifying," the "Hangover" star said.

2010: Ryan Reynolds

Ryan Reynolds' forthcoming role in "Green Lantern" — and his self-deprecating humor — helped him become the first Canadian Sexiest Man Alive.

"The most difficult part is going to be organically working this title into a conversation with random strangers," he told the magazine.

2009: Johnny Depp

Johnny Depp landed on his second cover on the heels of his role in "Alice in Wonderland."

He has since fallen out of favor with many fans. Depp has been repeatedly accused of domestic abuse by his ex-wife, Amber Heard, a claim that she continues to maintain. He denies it.

2008: Hugh Jackman

Hugh Jackman was named Sexiest Man Alive after his turn as Wolverine in "X-Men: The Last Stand."

2007: Matt Damon

Matt Damon was given the title after his third "Bourne" movie rocked the box office.

2006: George Clooney

George Clooney became the third man, after Brad Pitt and Richard Gere, to win People's honor twice.

2005: Matthew McConaughey

Matthew McConaughey scored the cover for People's 20th anniversary of Sexiest Man Alive after he became known for starring in popular romantic comedies, like "The Wedding Planner" and "How to Lose a Guy in 10 Days."

2004: Jude Law

Jude Law scored People's most famous cover in the early 2000s.

"He's the most beautiful man who ever walked the earth — an absolutely perfect oil painting," Naomi Watts told People in 2004.

2003: Johnny Depp

In 2003, Depp had charmed the world as Captain Jack Sparrow in "Pirates of the Caribbean: The Curse of the Black Pearl."

2002: Ben Affleck

The world couldn't stop talking about Ben Affleck and Jennifer Lopez in 2002.

"Chicks gravitate to him," Affleck's friend Kevin Smith, a director, told People at the time. "The word on the street is that he's the ideal man, chatty, gorgeous, generous, and intelligent."

2001: Pierce Brosnan

Pierce Brosnan was known as James Bond when he landed on People's coveted cover.

2000: Brad Pitt

In 2000, Brad Pitt was already a movie star — but coming off his wedding to Jennifer Aniston and his iconic role in "Fight Club," People decided to bestow Pitt with his second Sexiest Man Alive title.

1999: Richard Gere

When Richard Gere was named the Sexiest Man Alive in 1999, his ex-girlfriend Diane Von Furstenberg spoke glowingly of the decision.

"He walked like a biker, and that attracted me," she told People. "I knew I was going to get my hands on him."

1998: Harrison Ford

Harrison Ford's 1998 cover recognized his role as a blockbuster heartthrob thanks to "Star Wars" and "Indiana Jones."

1997: George Clooney

Clooney secured his first Sexiest Man title while portraying the brooding Dr. Doug Ross on "ER."

1996: Denzel Washington

Denzel Washington became the first man of color — and the first of only five total — to grace the Sexiest Man Alive cover.

1995: Brad Pitt

A long-haired Pitt made the 1995 People cover after his much-celebrated starring roles in "Legends of the Fall" and "Interview With the Vampire."

Keanu Reeves was retroactively named 1994's Sexiest Man Alive.

Technically, "John Wick" star Keanu Reeves never starred on People's cover; the magazine didn't select a Sexiest Man Alive in 1994.

But the editorial director retroactively bestowed People's honor on Reeves in 2015.

1993: Richard Gere and Cindy Crawford

In 1993, People forwent the Sexiest Man Alive cover in favor of naming a Sexiest Couple Alive. The magazine chose the newly married couple Cindy Crawford and Richard Gere, who split one year later.

1992: Nick Nolte

In 1992, People explained Nick Nolte's appeal as his being a "big-lug Adonis with the heart of gold."

1991: Patrick Swayze

In 1991, Patrick Swayze had become one of Hollywood's most popular leading men, thanks to "Dirty Dancing" and "Ghost." The actor died in 2009.

1990: Tom Cruise

By 1990, Tom Cruise had already starred in a string of blockbusters, including "Top Gun," "Risky Business," "Rain Man," "Cocktail," and "All the Right Moves."

1989: Sean Connery

Sean Connery was 59 when he scored the coveted cover, making him the oldest Sexiest Man Alive to date.

1988: John F. Kennedy Jr.

John F. Kennedy Jr. — known in 1988 as political royalty, but something of a rebel — is one of only two winners to have died in the years since his cover. Kennedy was killed in a plane crash in 1999 with his wife, Carolyn Bessette-Kennedy, and his sister-in-law, Lauren Bessette.

1987: Harry Hamlin

Harry Hamlin made the cover during his five-year stint on the NBC legal drama "L.A. Law" as attorney Michael Kuzak.

The "Clash of the Titans" actor is now married to "The Real Housewives of Beverly Hills" star Lisa Rinna.

1986: Mark Harmon

Mark Harmon received the second annual honor — largely thanks to his starring roles on two hit shows, "St. Elsewhere" and "Moonlighting."

1985: Mel Gibson

Mel Gibson was named People's first-ever Sexiest Man Alive after his star-making turn in the original "Mad Max" trilogy.

In the years since, Gibson has become a controversial figure thanks to rampant antisemitism, racist rants, and a recording of him making a death threat against his ex-girlfriend.

Ahead of his 2025 inauguration, President Donald Trump named Gibson as one of his ambassadors to Hollywood, tasking them with bringing business back to the film industry.

Investors who buy idle sanctioned tankers and refit them could put the ships back into legal oil trade, US Energy Secretary Chris Wright said on 19 October, Bloomberg reported. He laid out the plan five days after a US official described it to Reuters.

That official said the aim was to cut record tanker freight rates. The Energy Department added that any relief would not help Russia move its oil. The plan comes weeks before the 3 November midterms, with voters worried about fuel costs after gasoline and diesel prices surged in the Mideast conflict. Yet the shadow fleet is also how Russia sells oil past sanctions, and those sales fund its war against Ukraine. In December 2025, Ukraine’s foreign intelligence counted more than 1,100 tankers serving Russia alone, 226 of them under US sanctions.

An approval process Wright didn’t detail

Many sanctioned tankers sit idle, Wright told Bloomberg’s Annmarie Hordern, and buyers keep approaching the administration offering to fix them up and carry only legal oil.

“We’re going to move some of the ships from what I call the ‘bad-guy fleet’ to the ‘good-guy fleet,’” he said. “They will not carry sanctioned oil anymore.”

The ships must go through an approval process, Wright said, but he gave no criteria. He insisted “there is no removing of sanctions.”

He put the global dark fleet at about 1,600 ships, a count covering vessels that hauled Venezuelan, Iranian, and Russian oil. Dozens or even hundreds could turn legitimate, he said. The ships are no longer needed for Venezuelan oil, Wright said, and no Iranian oil is moving. Russian oil exports, he added, “are certainly not growing.”

Diesel, a waiver, and the tankers

Earlier, on 9 October, the Treasury issued General License 135, allowing some deals in Russian diesel until 7 April 2027. On 16 October, US President Donald Trump waived sanctions and tariffs under the Graham Act, leaving earlier sanctions intact. That law had directed him to review and sanction shadow-fleet vessels. Trump defended the waiver as a way to keep Moscow at the negotiating table.

House Speaker Mike Johnson told Fox News host Larry Kudlow on 18 October that he had asked the White House team to “carefully consider the unintended consequences,” The Hill reported. He added that he thought “the right decision will be made” in the end.

Mark Johnson | The Atavist Magazine | September 2026 | 2,048 words (7 minutes)

This is an excerpt from issue no. 180, “The Family Plan.”

At first she told no one. Not her twin sister. Not her mother. Not even her father the scientist.

Six-year-old Jenna Smith knew better than to pee when she was in the bath. But on that night in 1992, in her family’s home in Iowa City, the water felt so comfortable against her skin that she didn’t want to get out of the tub. It seemed like such a small thing. Who would know?

Seconds later the water around her waist turned reddish pink. Blood? It had to be. Jenna wondered if she’d hurt herself. “I was six years old sitting in a bathtub, watching a few seconds of my world stop making sense,” she would recall years later.

She kept the blood a secret because she didn’t want to admit that she’d peed in the bath. But when it was still in her urine the next time she used the toilet, she went to her mother. Concerned, her mom called her dad, Richard Smith, and he took Jenna to the emergency room.

Richard was an ear, nose, and throat doctor in the University of Iowa’s school of medicine, a researcher who would become one of the world’s authorities on the genetics of hearing loss. His wife, Lynne Lanning, had worked as both a lawyer and a nurse. They had four young children: twins Jenna and Jessica, who were identical, and two boys, Luke and Rion.

At the ER, doctors ran tests on Jenna, but they couldn’t identify the cause of the blood. In the days that followed the bleeding intensified. At her parents’ urging, Jenna collected samples of her urine in Dixie cups for further testing. The doctors remained stumped, however, and after a while Jenna found the whole thing more annoying than worrisome.

The uncertainty was much harder on her parents. It wasn’t that doctors were misdiagnosing their daughter; they were unable to diagnose her at all. “It was horrible,” Richard said. “Imagine seeing your child and you know something is wrong, and you know the doctors treating her have no clue what to do.” Richard called a pediatric nephrologist he knew in Houston, where the family had lived previously. The nephrologist listed several conditions that could be causing the bleeding and said that, to determine which was to blame, Jenna’s parents should take her to Cincinnati Children’s Hospital Medical Center.

In July 1992, Richard, Lynne, and Jenna drove nearly 500 miles to get answers. Doctors in Cincinnati diagnosed Jenna with dense deposit disease, a condition in which proteins clog and damage the kidneys, leading to renal failure in many patients. There was no cure.

The hospital couldn’t tell the family much else—no one could. The disease was exceedingly rare, afflicting between one and three people in a million. Back home, Richard and Lynne spent hours inside the University of Iowa’s quiet medical library, poring over papers in search of information about their daughter’s illness. They could find no evidence that anyone was actively studying the condition.

Although many Americans—roughly one in ten—suffer from a rare disease, the experience can be lonely. Friends and relatives don’t understand the unique miseries such illnesses impose on daily life. Few doctors are likely to have encountered them before. And because there aren’t many patients, drug companies usually don’t invest in research for treatments.

Richard and Lynne feared that their daughter’s life might be tragically brief. Sometimes the mention of weddings would sink Lynne into melancholy; she couldn’t bring herself to watch the movie Father of the Bride. Richard agonized over what to do. His training compelled him to seek answers, but he wanted to be Jenna’s father, not the scientist charged with curing her. He kept his research focused on hearing loss. At first, anyway.

Stories of scientific discovery almost always celebrate individual researchers, consigning the contributions of loved ones, communities, and colleagues to footnotes. There are exceptions―the teams that built the first atomic bomb and deciphered the human genome, for instance. Science also has its share of famous families. Marie and Pierre Curie, along with their daughter Irène and her husband, Frédéric, won five Nobel Prizes between them for discoveries related to radioactivity. For the most part, however, the history of scientific progress has been mythologized as a succession of brilliant, driven individuals—often men—who chose the lab over the dinner table and competition over collaboration.

Some scientists have embraced the role of maverick. “You have to worry about your own work and ignore what everyone else is doing,” the physicist and Nobel laureate Richard Feynman is said to have told a colleague. The decades-long pursuit of a treatment for Jenna’s disease followed a very different path. There was no single hero, no lone scientist seeking glory. The biomedical quest required the efforts of a family and their neighbors in Iowa City, and the work of scientists around the globe. Together they changed an obscure area of medicine.

Richard and Lynne met in 1977, when both were working at Memorial Hermann-Texas Medical Center in Houston—she as a nurse, he as a medical intern. He noticed a run in her nylons and was smitten by her smile. She liked his down-to-earth manner and intelligence, his humor and kindness. They were working in the hospital’s burn unit when he asked her out.

The couple married in 1981, and except for two years in England, they remained in Houston until 1990. That December they moved to Iowa City, where Richard had a job waiting for him leading the pediatric otolaryngology division and running a research lab at the University of Iowa’s medical school. They had been there only a year when Jenna got sick.

Richard and Lynne learned that their daughter’s disease was caused by a malfunction in her complement system. Believed to have evolved long before other parts of our immune infrastructure, the complement system sends proteins to battle foreign invaders. Unlike antibodies, these proteins are not tailored to fight a specific virus or bacteria, but they kick into gear faster when a threat is detected. In people with Jenna’s condition, the complement system is like a runaway train: Proteins become overstimulated and then accumulate in the glomeruli, tiny filters the kidneys use to clear waste from blood.

Blood in the urine is one symptom of the disease. Others include swelling, high blood pressure, inflammation, and fatigue. When Jenna was in the first grade, her body struggled to make growth hormones. Her production of red blood cells slowed, and she grew increasingly tired. During rehearsals for The Nutcracker ballet around Christmas 1993, she’d finish her part and then lie down backstage, completely spent.

Doctors put her on a heavy dose of the steroid prednisone and on blood-pressure medication. The prednisone caused her body to retain water. She woke up each morning with her eyes swollen shut, then waited in bed until the swelling receded. She couldn’t fit into her clothes or shoes. She wore flip-flops and roomy jumpers Lynne sewed for her.

As twins, Jenna and Jessica had always been close. They played together, made up songs and dance moves, explored the woods near their home, and enjoyed pranking friends and family members. “She made a lot of things feel not so heavy,” Jenna said of her sister. Still, she sometimes thought that Jessica “got off scot-free” by not having dense deposit disease. Neither girl liked feeling different from the other. (Years later, Jessica would be diagnosed with type-1 diabetes; Jenna would not.)

The changes to Jenna’s appearance meant the girls were no longer identical. Once, according to Lynne, when a boy at school said that Jenna couldn’t be a twin anymore because of how she looked, Jessica slugged him. Lynne recalled sitting in the principal’s office, politely listening to a lecture—this is not the way we resolve things!—but understanding why Jessica had lashed out. Nothing was so frightening to her daughters as the idea that they’d stop being twins.

About half of those afflicted with Jenna’s disease progressed to kidney failure within a decade of diagnosis; it took her less than a year. She made it through the last day of first grade. Then, as other children departed for summer camp, she went to a clinic. While her classmates practiced archery and did arts and crafts, she learned about the catheter doctors would surgically insert in her body. Through that tube, a machine would pump fluid into her abdomen, where her peritoneum—her abdominal lining—would take over the filtering function kidneys usually perform.

She would take the peritoneal dialysis machine home with her and use it every day for the foreseeable future, possibly for the rest of her life. When a nurse tried to take Lynne aside to show her how to operate it, Jenna stopped her. “I’m the patient,” the seven-year-old insisted. “I’m learning how to run the machine.”

In such moments, Lynne was surprised at the strength she drew from her daughter. She needed it. Her grief could leave her feeling drained. One day she found herself crying into the soil as she gardened.

But Lynne and Richard were determined that sadness would not define their lives. For a long time, they didn’t have a TV in their house—they wanted the family to talk when they were together, and for the children to build forts, learn to sew, be creative. They had painting nights, creating portraits of one another. There were cooking contests, too. Richard and Lynne made sure to spend one-on-one time with each kid. Richard traveled with Luke to Japan, with Rion to the Grand Canyon, with Jessica to Italy, and with Jenna to England. Lynne took trips with the children to Brazil, England, and Guatemala. There were themed birthday celebrations: a James Bond party for Richard, where everyone was armed with Nerf guns, and one for Lynne where Richard dressed as the artist Bob Ross and the guests painted “happy little clouds.” Richard coached the kids’ hockey and soccer teams. He built harps and lyres from scratch, and Lynne played them.

Every day, Richard left for work at 5 a.m., while the children were still in bed. He returned around six at night. The family joked that they could hear him coming from half a mile away in his rust-bucket Isuzu Trooper with the bad muffler and a hole in the passenger footwell. When he wasn’t seeing patients or in surgery, Richard was in the lab. On Saturdays, Luke would go there with him. Sometimes the other kids joined. They liked to refill the communal candy jars and visit the mice used in experiments.

It seemed a wonder to the lab’s staff that Richard squeezed so much into a day. When they began using email to communicate, they received messages from him time-stamped three or four in the morning. “Why don’t you sleep sometime?” a colleague replied once. Indeed, Richard slept little. At night his mind kept running through the mysteries of his daughter’s disease.

Richard had read that it took 10,000 hours—the equivalent of working full-time for about five years—to achieve expertise in a subject. He believed it. In 1995, he began flying to conferences about kidney disease, where he talked to the few doctors who cared for patients like Jenna. Medicine was getting no closer to finding a treatment.

That year the owner of a ranch where Richard and Lynne’s children took riding lessons offered to host a fundraiser for kidney disease research. The family organized Dressage in the Heartland, which featured riding events, fiddle music, and bowls of chili. After raising upwards of $10,000 for the National Kidney Foundation, they held the event again the following year. There are hundreds of kidney ailments, however, and the foundation didn’t allow the money the family raised to be earmarked for the research of dense deposit disease. (The foundation said it now allows monetary gifts to be dedicated to specific conditions.)

Richard and Lynne ran into more disappointment during a visit to the University of Minnesota in early 1997. A specialist they consulted was blunt. “Nobody is looking at this disease,” he told them. “And barring something unforeseen, nothing will be done in the next twenty years.”

It was a four-and-a-half-hour drive back to Iowa City. In the car, Lynne brought up what the doctor had said. Maybe they would have to be that unforeseen something.