Uma mensagem atribuída à suposta proprietária de uma casa noturna de Rio Verde, no sudoeste de Goiás, provocou repercussão nas redes sociais após a divulgação de uma ameaça de exposição de clientes casados e identificados politicamente com a direita. A manifestação teria ocorrido em resposta à inclusão do estabelecimento em uma lista de boicote contra empresários associados ao PT. A publicação foi feita pelo perfil Espia Só Goiás (@espiasogoias_).

No conteúdo compartilhado, uma mulher identificada como Maria afirmou que seu estabelecimento passou a integrar uma relação de empresas alvo de boicote em razão do voto declarado no presidente Luiz Inácio Lula da Silva (PT). A suposta empresária atribuiu a iniciativa à intolerância política contra eleitores petistas.

A reação descrita na publicação ultrapassou a disputa político-partidária. A autora da mensagem ameaçou divulgar nomes de clientes que, segundo sua declaração, seriam homens casados e apoiadores da direita. A exposição poderia atingir a privacidade dos frequentadores e provocar consequências pessoais e familiares.

A mensagem apresentou a frase “Com ferro fere, com ferro será ferido”, em referência à possibilidade de responder ao suposto boicote com a divulgação de informações sobre a vida privada dos clientes. O conteúdo associou a ameaça à disputa política e ampliou a repercussão do episódio.

Até o momento, não houve confirmação independente da identidade da mulher, de seu vínculo com qualquer estabelecimento comercial ou da autenticidade da publicação. Também não foram comprovadas a existência da suposta lista de boicote e a veracidade das informações atribuídas aos frequentadores.

A circulação da mensagem reacendeu o debate sobre discriminação por preferência partidária, boicotes comerciais e proteção da intimidade. A liberdade de manifestação política constitui direito fundamental, mas não afasta a responsabilidade por eventuais violações à honra, à imagem e à vida privada de terceiros.

The post Casa noturna entra em lista de boicote e suposta dona ameaça expor clientes casados em Rio Verde appeared first on Diário da Manhã - O Jornal do leitor Inteligente.

• A new study explored the differences between tumors in younger and older colon cancer patients.
• Younger patients sometimes had more aggressive, treatment-resistant forms of colon cancer.
• Staying active, cutting down on processed foods, and getting screened are good ways to lower risk.

People under 50 aren't only at a higher risk of colon cancer today than they were a few decades ago. They're also developing a different, sometimes more aggressive form of it compared to older patients, scientists say.

A new study published in Nature Medicine analyzed 189 tumors from colorectal cancer patients aged 29 to over 90, including measurements of gene activity in more than 850,000 cancer cells.

The goal was to look at how tumors varied "across the entire spectrum of age," Dr. Ana Anderson, a co-senior author of the study who leads the cancer immunology program at the Gene Lay Institute at Brigham and Women's Hospital in Boston, told Business Insider. "Is it the same colon cancer but just happening in younger people, or is there something different about it?"

As a result, the study was able to map out gradual, subtle differences in colorectal cancer tumors correlated with age. While the researchers couldn't pinpoint exactly why tumors in younger people look different, Anderson said the study is an exciting starting point for further research.

"There's a lot of interest in lifestyle factors and environmental exposures as potential contributors; however, nothing specific has been pinned down," Anderson said. "What we did is take a rather simple but comprehensive approach just to try to understand the disease itself."

Younger patients' tumors had a different cellular makeup

The study's researchers couldn't definitely state that colon cancer in younger patients is always more aggressive — that would require more study.

However, what they did find was that younger patients "generally have more aggressive disease and they are generally more resistant to the standard of care therapies, which is mostly chemotherapy," Anderson said.

Tumors in younger patients generally had a higher presence of supporting and connecting cells known as stromal cells. Stromal cells, such as fibroblasts, can produce factors that suppress the immune response, making it harder for chemotherapy drugs to work. "They essentially can form a shield that protects the tumor from infiltration," Anderson said.

The study found that the presence of stromal cells generally declined from younger to older patients, and the youngest patients tended to have the highest number of stromal cells in proportion to cancer cells.

The reverse was true for the oldest patients, who generally had the fewest stromal cells and the highest numbers of cancer cells.

Researchers narrowed down where to look for answers

Younger patients also had higher activity of long non-coding RNAs (lncRNAs), which are associated with cellular signaling in cancer. The study also found gene activity in younger patients that suggested stronger signaling between cells — potentially helping cancer cells move and invade nearby tissue.

The problem is, lncRNAs are still a fairly recent discovery; they only became linked to cancer research in the late 2000s, with some poorly understood ones referred to as "dark RNAs." "A lot of them have just not been researched, and that's why they're called 'dark RNAs' — it's a big mystery," Anderson said.

For that reason, she said it was the finding she considered most promising. "There's a world of biology to be discovered there — we know where to focus our research efforts," she said.

Anderson, an immunologist, also hopes to explore the presence of immune cells in younger colon cancer cases, as immune cells are involved in killing cancer cells but were "under-captured" in this study, she said. "There are many types of immune cells," she said. "Are there different subsets that are more present in the young tumors or absent in the young tumors versus the older tumors?"

Reduce your risk with these simple habits

While the study doesn't present any immediate new takeaways for young people concerned about colon cancer, Anderson suggested following existing guidance for lowering your risk.

She noted that the recommended screening age for most people was lowered from 50 to 45 a few years ago, but that it's wise to see a doctor sooner if you experience common colon cancer symptoms like rectal bleeding, abdominal pain, bloating, or changes in bowel movements.

If you're "extra cautious," she said, it's never a bad idea to stay active and cut down on inflammatory foods such as ultraprocessed snacks and alcohol.

Japón, en el siglo XVI, estaba más cerca del territorio español de lo que podríamos suponer a primera vista. Sus piratas protagonizaban incursiones en Filipinas, un archipiélago que por entonces se hallaba bajo dominio hispano. Pero, por otra parte, las dos potencias también se relacionaban en términos diplomáticos. Basta con recordar la embajada nipona que llegó a Sevilla en tiempos de Felipe III. Todavía quedan descendientes de aquellos representantes del imperio del Sol Naciente.

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