O Pedras Salgadas entrou melhor e, aos 8’, abriu o marcador, lançamento longo para a área, onde Romer cabeceia para defesa incompleta de Markito, com o mesmo jogador a aproveitar para colocar a bola no fundo das redes. No minuto seguinte esteve perto o segundo, mas o remate de Jorge Jesus sai ao lado. Aos 10’, o Cumieira reagiu e criou uma situação de aparente perigo, Zé Pedro, com um remate de fora da área, obriga Rafa Mateus a uma excelente defesa para canto. Já com a partida equilibrada, ambos os conjuntos criavam oportunidades de golo, mas a eficácia era nula. Aos 28’, o Cumieira esteve perto do golo, valeu mais uma boa intervenção de Rafa Mateus ao remate de Gabi. Aos 33’, de novo, Rafa Mateus evita o golo ao desviar um remate de Marinho ao poste, com Zé Pedro a não conseguir a emenda. Aos 39’, o Pedras Salgadas aproveita uma perda de bola do Cumieira e com uma saída rápida, a bola chega a Tomás Magalhães, que remata ao lado.
Logo a abrir a segunda parte, os da vila termal estiveram perto do golo, remate de Banora ao poste esquerdo da baliza de Markito. Aos 48’, Romer bisa, após um lançamento longo para a área, com o golo de cabeça. O mesmo Romer fez o “hat-trick” aos 50 minutos. Com uma vantagem confortável, o Pedras Salgadas tentou controlar a partida, sem criar ocasiões de golo. Já o Cumieira procurava o golo, mas sem grandes soluções no ataque. Aos 89’, o Pedras Salgadas eleva a contagem, cruzamento da direita de Bruno Sul para a cabeça de Hugo Alexandre, que bate Markito mais uma vez. Em cima do minuto 90, Banora alcança o quinto golo, terminando o jogo com uma goleada imposta pelo Pedras Salgadas, que segue firme na segunda posição da tabela com menos um ponto do que o Vila Real.
FICHA TÉCNICA Campo da Flávia, em Cumieira Árbitro: André Santos Auxiliares: Fernando Nunes e Filipe Ferreira
CUMIEIRA: Markito; Rafa, Itó (Del Piero, 50’), Marinho (Matos, 70’), e Ayoub; Gabi, Camará (Hugo Almeida, 53’) e Simão (Fontes, 53’); Penelas, Patrick e Zé Pedro Treinador: José Ribeiro
PEDRAS SALGADAS: Rafa Mateus; Pedro Silva, Gonçalo Almeida, Maga (Hugo Alexandre, 60’) e Fábio Carvalho; Romer (João Silva, 70’), Banora e Tomás Magalhães (Daniel Jordão, 83’); Jorge Jesus, Gabi (Bruno Sul, 83’) e Simão Treinador: Marco Martins
Ao intervalo: 0-1 Cartões amarelos: Pedro Silva (38’), Gabi (67’) e Tomás Magalhães (81’) Marcadores: Romer (8’, 48’ e 50’), Hugo Alexandre (89’) e Banora (90’)
Kramer says international membership growth, the Oscars-YouTube deal, and a new festival-qualifying pathway to nomination are all part of the organization’s expanding worldwide ambitions.
Costumamos pensar que temos um cérebro só nosso, feito do nosso próprio ADN. Não é bem assim. Escondidas lá dentro há células de outras pessoas: da nossa mãe e, para quem já esteve grávida, dos nossos filhos. Durante a gravidez, células maternas atravessam a placenta e células fetais fazem o caminho inverso. Algumas ficam muito depois do parto. Chama-se a isto microquimerismo, e sabemos agora que algumas dessas células se fixam no cérebro. É uma herança celular que corre nos dois sentidos. A colunista Helen Thomson, que teve filhos a partir de óvulos doados, resume o seu próprio caso: os
Los amantes de la gastronomía tienen un lugar en el mundo donde perderse: Barcelona. La capital catalana lleva décadas ocupando un lugar privilegiado en el mapa gastronómico internacional gracias a una cocina que ha sabido innovar pero a su vez mantener la tradición y seguir conectada con el territorio. El futuro de la gastronomía barcelonesa no nace de cero. Es el resultado de una evolución que hoy entra en una nueva etapa marcada por una mirada renovada hacia el producto local y una forma distinta de entender la restauración en la era del Me gusta.
Azucena (Suzy) Reyes, now 43, was diagnosed with stage 3B colon cancer in her early 30s.
Suzy Reyes
Azucena "Suzy" Reyes went to the ER several times for nausea and stomach pain.
After months of back and forth, she finally learned she had a mass in her large intestine.
Despite first being told she was 'too young' for colon cancer, she was diagnosed at stage 3B.
No matter how healthy she tried to eat or how often she ran 4 miles at her community college, Azucena "Suzy" Reyes felt bloated in her stomach.
"I looked like I was pregnant," Reyes, who's 43 and based in Alvin, Texas, told Business Insider. At 32, she was studying to be a certified nurse assistant while running a construction company with her husband and raising their four children together.
Then, her symptoms got worse. She was frequently exhausted, which she attributed to working out and being busy. She started getting fevers and feeling intense nausea. There was also her severe stomach pain.
"I really thought it was an ovary that had burst because it was that painful," she said.
Between August and October in 2015, Reyes went to the ER four times, originally diagnosed with inflammation in her intestines. When she finally saw a GI doctor in October, she was sent to the ER a fifth time, where she had emergency surgery and learned she had stage 3 colon cancer.
"I was scared because I did not know anything about colon cancer," Reyes said. "It was very, very dramatic to me because I didn't want my children to go through the fear of thinking that I was going to die."
She was told she likely didn't have cancer because of her age and race
After the ER staff looked at her vitals, Reyes was first diagnosed with colitis and enteritis, inflammation of the small and large intestines, as well as a microperforation. She was sent home with antibiotics. When the pain didn't go away, she returned to the ER and was put on a PICC line to administer medication and kept in the hospital for three weeks. Around the same time, Reyes tried to book a GI appointment and was put on a waitlist until early October.
When the PICC line was removed, the nausea came back. The next two ER visits didn't yield more answers. By the time she finally saw her GI, she couldn't keep still long enough because she kept throwing up.
Within hours, Reyes and her husband went to the ER a fifth time, where an ultrasound revealed a tumorthat had completely obstructed her transverse colon, the longest part of her large intestine, and made it difficult for her to keep food down. The next morning, she had emergency surgery to remove it.
Reyes was first told she likely didn't have colon cancer because it's rarer in Hispanic populations.
Suzy Reyes
At first,Reyes said, the surgeon told her not to worry about the tumor. He told her she was very young, and that colon cancer wasn't as common in Hispanic populations and people under 60.
But a week later, she learned she had stage 3B colon cancer. "I was scared, but then relieved at the same time," Reyes said. "For three months, I was suffering, and I didn't know why."
Worried about worrying her family
The original plan was to hide her diagnosis and treatment from her family, especially her four kids, ranging in ages from 4 to 16 at the time. The doctor said she would likely only need two or three rounds of chemotherapy. Reyes and her husband wanted to leave their children with her mother and say they were going on a long couple's trip for about a month.
Once she met with her oncologist and learned that the cancer had grown through her muscular wall and into her lymph nodes, she learned she would need 12 rounds of chemotherapy — about six months of treatment. It would be impossible to keep a secret. "I just didn't want anybody to suffer, like my children and my parents," Reyes said.
Reyes experienced side effects from the chemo, such as nausea, fatigue, and weight gain. "I was literally swollen," she said. "It's like they pumped air into me."
All the while, she avoided looking up colon cancer or trying to research her prognosis online — something she said helped her maintain a "peace of mind" throughout treatment.
She now advocates for cancer awareness in Spanish-speaking communities
As of October 2026, Reyes has been cancer-free for over a decade. She says she continues to receive annual follow-ups, including colonoscopies, blood work, and CT scans.
Reyes now advocates for greater colon cancer awareness, particularly in Spanish-speaking communities.
Suzy Reyes
Some of her treatment side effects haven't gone away. "The neuropathy in my feet, arms, fingers — it just feels like needles poking them," she said.
After she was diagnosed, she urged her brother, who was 42 and a few years below the recommended screening age of 45, to get a colonoscopy. After some resistance, he agreed — and learned he had colon cancer as well. After surgery to remove his tumor, he's been cancer-free for 4 years, she said.
Looking back, Reyes said shehad wanted more guidance from other people who had colon cancer. She remembered posting about her experience on social media, but "nobody ever reached out to me and said, 'Hey, I'm an advocate for colon cancer. I'm here,'" she said. "I wish I would've had that."
Reyes is now involved with the Colorectal Cancer Alliance's Never Too Young Taskforce, as well as a few other groups. She also tries to focus on helping the Spanish-speaking community. "There are so many people that come out to us, me and my husband, and they're like, 'Thank y'all for doing this,'" she said.
Dois dias após a vitória de Luiz Inácio Lula da Silva (PT) nas Eleições 2026, o ex-presidente Michel Temer (MDB) pediu que o mandatário trabalhe para pacificar o país e reúna os Três Poderes e representantes da sociedade civil para uma “grande conversação nacional”.
Sem citar nominalmente Lula, Temer afirmou desejar que “o presidente reeleito faça o possível para impedir a agressividade que tem resultado em divisão dos brasileiros e até das instituições”.
Ainda na manifestação desta terça-feira (27), ele disse que Lula deveria convocar os representantes do Estado brasileiro e da sociedade, inclusive forças da oposição.
Segundo Temer, a conversa serviria para uma “tranquilização do país e um ambiente de confiança” que, segundo ele, ajudaria no crescimento da economia.
“A harmonia entre todos os setores do país é fundamental e determinação da Constituição Federal”, reiterou.
Mientras trabaja en Vitaminas, la frutería familiar del barrio madrileño de San Pascual, este creador de contenido arrasa en redes bajo el nombre de El Frutero Tiktokero y acerca el mundo de las frutas a más de 1,2 millones de seguidores Leer
Mientras trabaja en Vitaminas, la frutería familiar del barrio madrileño de San Pascual, este creador de contenido arrasa en redes bajo el nombre de El Frutero Tiktokero y acerca el mundo de las frutas a más de 1,2 millones de seguidores
Democrats are targeting G.O.P. strongholds that could set them up for new majorities. But if they don’t win those races now, it could be a long time before they have another chance.
Protesters outside of an event for Senator Roger Marshall in Topeka, Kan. Soaring fuel costs and economic struggles have made some Republican senators like Mr. Marshall vulnerable on their home turf.
Losing Chagos would end the claim that the sun never sets on the British Empire. From Bermuda to Pitcairn, the UK's remaining territories form an unrivalled network worth keeping, argues James Alexander.
Michigan Gov. Gretchen Whitmer (D) pushed back on former first lady Michelle Obama’s remarks that the U.S. was not ready to elect a woman president. Appearing on NBC’s “Meet the Press,” about Obama’s past comments, Whitmer responded, saying, “Listen, I have got a lot of colleagues who I think are probably interested in running for…
Dr. Ben Hagopian sees patients through Direct Primary Care. He also made the switch for his family of four, combining DPC with a cost-share group.
Courtesy of Ben Hagopian.
I've been a doctor for more than a decade and have a family of four.
I've traded traditional health insurance for direct primary care and a medical cost-sharing group.
For the first time, I feel like I'm truly in control of our healthcare.
I've spent more than a decade navigating the labyrinth of American healthcare. I've worn the white coat, spent sleepless nights on call, signed the charts, and cared for thousands of patients.
A few years ago, I realized I couldn't keep participating in a system that felt like it was designed to fail the very people it was meant to serve.
Today, my family and I are uninsured in the traditional sense — and I'm confident that it's the best financial and medical decision I've ever made.
I hit my breaking point
For years, I worked in a traditional, insurance-based primary care practice. My days were a blur of 15-minute appointments, dictated not by medical necessity, but by billing codes and insurance reimbursements. I felt completely beholden to the behemoth of corporate medicine. Patients were waiting months to see me and were almost always shortchanged on the time I was able to spend with them.
I felt like the insurance companies were the invisible third party in every exam room, deciding which tests I could order and which medications my patients deserved. I wasn't just a doctor anymore; I was a data-entry clerk for multibillion-dollar payers. The result was a total, soul-crushing burnout that followed me home every night.
On the other side of it, some of my patients were forgoing necessary care because the costs presented to them were simply too high. Did it make sense to spend $300 to check a thyroid test to ensure the $10 per month medication I prescribed was working as it was supposed to? Many patients, rightfully so, decided to spend their money elsewhere.
I knew I had to get out — not just for my own sanity, but to actually provide the type of care I believed in.
Direct primary care offered something different
I eventually traded the treadmill for Direct Primary Care (DPC). In this model, my patients (or their employers or an insurance company) pay a flat monthly membership fee directly to me (around $100 per month). This type of care is affordable— my current patient panel includes attorneys, electricians, teachers, and retirees. There are no co-pays, no deductibles, and most importantly, no insurance companies breathing down my neck.
The difference was night and day. Without the administrative bloat of insurance billing, I finally became the doctor I trained to be:
Time: I went from seeing 20 patients a day to seeing six or eight.
Access: My patients can text me directly. We have hour-long conversations instead of 10-minute sprints.
Cost: By cutting out the intermediary, I'm able to offer wholesale pricing on labs and imaging that are often 90% cheaper than hospital rates. That $300 thyroid test from my previous job? I now offer that for $8.
I took my own family off the grid
Once I saw how much better medicine functioned without traditional insurance interference, I took the ultimate leap. I took my wife and children, now 9 and 6, off our health insurance plan.
Instead, we joined a medical cost-sharing community. It isn't insurance; it's a community of members who share each other's large, unexpected medical expenses. When I combined a DPC membership for our routine care with a health share for the big stuff, I realized I had found a better way to protect my family — and was paying far, far less for it.
The math backs up my decision
To understand why we left, look at the cost of childbirth. When our first child was born under a supposedly high-end traditional insurance plan, we still walked away owing about $10,000 after paying our insurance premiums. We were paying twice: once for the premium and again for the actual care.
My wife spent hours of her precious maternity leave arguing with insurance companies about the services we received in the hospital. When our infant son was hospitalized a few months later, she was back on the phone again, having to advocate for his coverage during the time of a family crisis. We spent years paying off the cost of the birth and his illness.
With our second child, we looked at the numbers through the lens of a cost-share program. On a plan like ours, the Initial Unshareable Amount (IUA) — the part we pay before the community kicks in — was only $1,500.
Beyond that $1,500, the community shared the rest. We didn't have to spend my wife's recovery time fighting with a claims adjuster or waiting for pre-authorizations. We knew exactly what our responsibility was, and more importantly, we knew our family was covered by a community, not a corporation.
I feel like I took back control
As a physician, I've seen the insurance trap from both sides. We've been conditioned to believe that without a blue or green plastic card in our wallets, we are unsafe.
The reality is that for some, traditional insurance has become a barrier to care rather than a bridge. By opting out and pairing Direct Primary Care with a health share, I've reclaimed my time as a doctor and my peace of mind as a father. I'm no longer waiting for an insurance company to tell me how to care for my kids or my patients. As a doctor and as a father, for the first time in my career, I feel truly secure.
Lynch syndrome, a hereditary condition that increases cancer risk, has no symptoms. Most people don't realize they have it until after a cancer diagnosis.
iStock; Tyler Le/BI
After Bryce Ramsey was diagnosed with stage 3 colon cancer at 33, she learned another piece of shocking news: She had a genetically high chance of developing it from the very beginning.
Ramsey tested positive for Lynch syndrome, a silent, inherited condition that heightened her lifetime risk of being diagnosed with colorectal cancer by up to 56% for her variant. It also put her at greater risk of developing ovarian, uterine, stomach, pancreatic, and other forms of cancer.
Before she learned she had Lynch, Ramsey urged her relatives to also get screened for colon cancer. Since then, her father, brother, and aunt have all been diagnosed with various stages of colon cancer. Like Ramsey, her aunt also tested positive for Lynch.
"I was the whistleblower," Ramsey, 40, based in Mississippi, told Business Insider. Ramsey now wants her two young sons to test for Lynch once they're in their early 20s, the recommended starting age for her specific Lynch mutation.
Bryce Ramsey only learned she had Lynch syndrome after being diagnosed with colon cancer.
Bryce Ramsey
Like most genetic testing, Lynch syndrome testing is relatively quick, cheap, and non-invasive. It involves a saliva test, a cheek swab, or a blood test, with the latter having the least room for error.
Still, it hasn't caught on: About 1 in 279 Americans (1.2 million people) are estimated to have Lynch syndrome, including between 3 to 5% colon cancer patients. Yet an estimated 95% of Americans with Lynch syndrome have no idea they have it.
All the while, cases of colon, breast, uterine, and pancreatic cancers are rising in young people, with colon cancer the deadliest cancer for adults under 50. "If you don't know, then you can't get help," Ramsey said, including earlier screenings or preventive measures such as hysterectomies.
"Ignorance is not always bliss."
The 'lowest hanging fruit' for cutting down cancer risk
Some experts view broader Lynch syndrome testing as a way to get more people screened for cancer before symptoms arise — and a way to potentially help entire families better understand their cancer risks.
Like Ramsey, the majority of people diagnosed with Lynch syndrome only get screened after they have cancer. In the US, the CDC's general guidelines recommend that colon and uterine cancer patients have tumors biopsied for Lynch, followed by Lynch syndrome screening for the patient if there are abnormal findings.
Some experts believe the lack of early genetic testing is a huge missed opportunity for reducing cancer risk. One 2021 study found that about 16.4% of 713 early-onset colorectal cancer cases could have been prevented if patients knew either their family history or had been genetically screened, and would have subsequently started getting colonoscopies sooner.
Lynch syndrome testing "has got so much potential, but it's not being utilized," Heather Hampel, a professor at City of Hope in California who specializes in clinical cancer genomics and Lynch syndrome, and a co-author of the study, told Business Insider.
While Lynch syndrome remains unknown to most Americans, some health systems are trying to expand testing to the broader population. Helix, a genetic screening company that first started out as a consumer DNA marketplace, started partnering with 17 health systems in 2021 as part of its "Population Genomics Initiative." The goal has been to introduce broader population-scale genomic programs that include testing for Lynch syndrome.
Helix offers broad, population-based Lynch syndrome testing through participating health systems.
Helix
Dr. Cassie Hajek, the medical director of Helix, told Business Insider that most patients diagnosed with one of these hereditary conditions by Helix were completely taken aback by the news. "They're kind of operating on the assumption that their risk is just as it is in the general population, but in fact, it's significantly elevated," she said. "The whole goal is to identify these patients hiding in plain sight."
By knowing their genetic predispositions for cancer, they can both more easily start earlier cancer screenings and also inform their family members of their potential genetic risks.
Hampel noted that lowering overall cancer rates is complicated. We still don't know why colon cancer cases are rising so rapidly among young people, and lifestyle factors like sedentary routines and diets high in ultra-processed foods are far more difficult to control for.
"If the lowest-hanging fruit is family history and gene testing, and we can't even prevent those," Hampel said, "how are we ever going to prevent things where we need people to make lifestyle or behavioral changes?"
The ripple effects for families
Michelle York was 33 when she first heard of Lynch syndrome.
Up until that point, all she'd known was that her mom's side of the family had a long cancer history. Her great-grandmother died from colon cancer. Her grandfather had stomach and brain cancer. Her great-aunts died from liver, ovarian, and breast cancer, respectively. Her mother's cousin died from pancreatic cancer.
York (second from left) with her mother, sister, and brother — all of whom tested positive for Lynch syndrome.
Michelle York
York's mother, a nurse at the time, had come across the term through her work. She tested positive for Lynch, along with York, her two siblings, aunt, uncle, and cousin.
At first, the news caused some anxiety. "Does this mean I'm going to get cancer at a young age?" York, 43 and based in Los Angeles, told Business Insider. "Does this mean every time I don't feel well, I'm going to immediately think I have cancer?"
However, once York and her family started getting routine cancer screenings, including annual colonoscopies, they felt more reassured than afraid, because they knew they could catch cancer early. York's mother had multiple precancerous polyps removed.
"None of us have had cancer yet, but we've had lots of scares," York said. She also wants her kids, ages 17 and 14, to test once they're older.
York's mother triggered something called "cascade testing," in which other family members test for Lynch and can take preventive measures to reduce their cancer risk.
Dr. Sapna Syngal, the director of research at the division of cancer genetics and prevention at the Dana-Farber Cancer Institute in Boston and the founder of its Lynch Syndrome Center, sees cascade testing for Lynch as a "real opportunity" to lower cancer risk, she told Business Insider.
Particularly for young people, if they test positive for Lynch in their 20s and start getting cancer screenings, "there's a really, really good chance that you could prevent that cancer by taking out polyps earlier on," she said.
There are also financial benefits to knowing you have a genetic predisposition to cancer. While insurance coverage for Lynch-related cancer screenings can vary, Hajek said her patients typically have a more "straightforward" experience in getting otherwise expensive screenings like colonoscopies covered. York, for example, said her insurance covered her cancer screenings once she got her Lynch syndrome diagnosis.
York, pictured with her family, wants her kids to test for Lynch syndrome when they're old enough.
Michelle York
Ultimately, Hajek said Lynch syndrome testing can help patients get more precise care than simply knowing they have a family history of cancer. Just as testing positive for Lynch can prompt someone to start cancer screenings sooner, testing negative can also relieve a person of anxiety about being at high risk of early-onset cancer and potentially call for less frequent cancer screenings than if they had Lynch.
York said she's ultimately grateful for finding out and knowing she can catch any early signs of cancer by starting annual screenings such as colonoscopies in her 30s — over a decade before the average-risk recommended screening age of 45. Both Ramsey and York also had hysterectomies and oophorectomies unrelated to cancer, which brought extra relief in also reducing their uterine and ovarian cancer risks to essentially zero.
"I think knowledge is power," York said. "Now, it almost feels comforting because I know that I started doing this young."
Lynch needs its Angelina Jolie
Angelina Jolie appearing on the red carpet a month after her May 2013 op-ed revealing her BRCA1 diagnosis and decision to undergo a preventive double-mastectomy.
LEON NEAL/AFP via Getty Images
In 2013, Angelina Jolie revealed in a New York Times op-ed that she had tested positive for BRCA1, a gene that increases the risks of breast and ovarian cancer.
Her revelation — and subsequent operations to remove her breasts and ovaries — sparked an international drive to get tested for BRCA1/BRCA2. Years later, a study found that 15 business days after Jolie's op-ed went live, BRCA testing rose 64% in the US.
Over a decade later, researchers and patients are working to make Lynch syndrome screening similarly universal.
Getting every person screened comes with its own obstacles.
Lynch could be added to the list of genetic conditions screened for in newborn heel tests. However, critics of the idea believe it can create years of stress when the person with Lynch isn't recommended to start getting colonoscopies until they're in their early 20s.
Other routes, such as including Lynch syndrome testing when people join the military or go to college, would miss broad swaths of the population.
There's also the question of funding. Helix, for example, doesn't bill patients and instead relies on the participating health systems for financial support. Few hospital systems can afford to prioritize testing for a gene condition that impacts a small portion of the population.
Ramsey's advocacy work includes raising more awareness around colon cancer as well as Lynch syndrome.
Bryce Ramsey
Syngal said one immediate option for getting more people screened for Lynch is to follow York's route: consider getting tested if you have a family history of colon or other relevant cancers.
Since their diagnoses, Ramsey and York have tried to spread the word about Lynch syndrome testing. Ramsey is an official advocate for the non-profit Lynch Syndrome Awareness, while York, a full-time content creator, has shared her story on social media.
"It's scary when you first find out that you have a genetic mutation that predisposes you to cancer," York said. "But at the end of the day, knowing that and taking those precautions could ultimately save your life."
It's the only drug that can shrink oil glands, potentially clearing pimples for good. But it comes with serious risks — primarily: a high rate of birth defects if you take it and become pregnant. Other side effects include sun sensitivity, high cholesterol, mood changes, and joint pain.
Parents are scared to put their teens on it. Dermatologists often reserve it for stubborn acne, after other creams, cleansers, antibiotics, and pills have been exhausted. And strict pregnancy-prevention rules mean monthly check-ins, tests, and blood work.
But in recent years, some of the stigma around the retinoid drug, generically called isotretinoin, has started to fade, as people have gravitated to a smaller, more strategic "Hollywood dose" of Accutane. By taking small amounts of the drug, maybe just a few days per week, many patients find they can maintain a dewy, glass-like complexion on camera while avoiding painful side effects like ultra dry skin, and the initial acne breakout purge that comes with heftier prescriptions.
"I love the Accutane glow-up," Honeydew dermatology founder David Futoran, 29, said. For him, it includes hair that's less oily, and baby-soft cheeks.
Futoran is partly responsible for turning Accutane from a maligned prescription of last resort into a buzzy internet sensation. He's found new ways to streamline and digitize paperwork, turning most of the required monthly doctor's office visits and testing for the drug into something people can do at home. Honeydew is now growing 3x year over year, Futoran said, and interest in low-dose prescriptions is increasing.
Dermatologists are divided on the trend of microdosed Accutane. Yes, it is a very effective drug, and it can clear up most breakouts. But there are tradeoffs to taking an intermittent or low-dose approach, and some doctors say why bother dancing around side effects when you could get on and off the potent drug in months, and have clear skin for life?
Founder mode for skin
David Futoran started Honeydew because he was so frustrated by monthslong wait times for dermatology appointments.
Honeydew
Futoran founded Honeydew in 2022 after spending years on various antibiotics and multi-step cleansing and cream routines, with his acne constantly coming back.
His vision was to make prescription acne care faster and more accessible. He partnered with his longtime dermatologist, Dr. Joel Spitz, to build a telemedicine platform connecting patients with providers and treatments for acne, rosacea, eczema, and psoriasis.
Yet Futoran was still hesitant to take Accutane himself, partly because of the logistical headaches.
One morning, he said, he woke up with a large, painful cyst in the middle of his forehead. That was it, he said — he decided he was finally going on the low-dose form of Accutane his company had been prescribing.
Futoran says he reached a breaking point when he woke up with this painful cyst on his forehead.
David Futoran
"I should have done that from the start," he said. "My skin is way less irritated than it ever was on any of the topicals, and I just have peace because I know it works."
Accutane works because it shrinks oil glands by turning down sebum production. It triggers the death of some stem cells, which is great for clearing up overactive oil-producing glands, but very bad for developing fetuses.
In addition to making regulatory compliance digital, Honeydew offers specially formulated lip balms, cleansers, antihistamines and supplements like Omega-3 designed to replace lost oil.
Bringing a celebrity skin trick to the masses
Mikey Narine, a model and influencer, was prescribed Accutane through Honeydew. He says his confidence has skyrocketed, and his face is totally clear.
Mikey Narine
Celebrities including Chris Pine, Pete Davidson, Emma Stone, and Kendall Jenner have all been open about using this powerful oral retinoid to help clear up persistent acne. The shadow business of microdosing Accutane, though, using it as a glow up drug even for minor, isolated breakouts, happens more through a whisper system between doctors and patients.
26-year-old marketing manager and social media influencer Kennedy Faris started microdosing Accutane with Honeydew in the spring. About a decade ago, she watched her little brother suffer some of the rarer mental health side effects of Accutane, and she was worried about the possibility the drug could lead to depression.
"My brother's a very happy person, so it was really scary," Faris told Business Insider. "I was really hesitant about starting."
After struggling to get a prescription from an in-person dermatologist, Faris heard about Honeydew from a follower and partnered with the brand. She started on a low dose of 10 milligrams, working her way up to a standard 40 mg dose over the course of a few months.
After years of trying different skincare products, antibiotics, and medications, she feels like she's finally found a more permanent solution to cystic acne. There are drawbacks to being on the drug, she said, including sensitivity to alcohol, sunlight, and some nightmares. But the real benefit has been her renewed confidence, optimism, and joy, with friends noticing she's "more bubbly and happy," she said. "I was like, 'wow, I was kind of depressed.'"
Because the drug shrinks pores, Faris has also noticed her face and nose appear slimmer.
"Everyone talks about the fake nose job," she said.
Some patients recovering from real nose jobs even use the drug to lower surgery-related inflammation and shrink pores on the nose while their face heals. As testosterone therapy booms, more men are taking Accutane to deal with oilier skin. And increasingly, patients are lining up for low-dose Accutane for minor breakouts, just to be in the clear. People are gravitating to skin treatments that will give them the edge at work and on screen, Spitz said.
"Everyone's on Zoom or Google Meets or they're on TikTok or they're on Insta, and they want to look good," he added.
The potential drawbacks of microdosing
Microdosing can ease side effects, but the results may not last as long.
Honeydew
Some doctors worry that microdosing Accutane could lead to more health complications if people stay on the medication for years at a time.
"In my practice, I just basically put people on the standard dose and then they're done at five months, and then they feel much better, Dr. Ariel Ostad, a dermatologist in Manhattan who is not affiliated with Honeydew, said. "Patients, once they go on it, their skin clears up really quickly, and they're happy, and they realize it's not as bad as they thought."
A shorter treatment course means less time worrying about drug interactions, liver or heart health, pregnancy, sun sensitivity, or bone issues.
Futoran said traditional dosing can be "absolutely the right answer for some patients," and roughly 40% of Honeydew prescriptions are at standard dosages. Still, he cites studies showing patient satisfaction is higher with low-dose Accutane, and said Honeydew patients on smaller dosages have "materially better retention."
"The best clinical outcome is when patients complete their course, but faster is not always better," he said.
De casas de sonho a histórias caóticas, The Sims transformou a vida quotidiana num fenómeno mundial. No Geração Gamer, Cristiana Reis recebe Mariana Bossy e Sara Mercury para recordar a série que deu aos jogadores liberdade para criarem os seus próprios mundos
Le phénomène El Niño touche la Nouvelle-Calédonie, provoquant moins de pluies et une sécheresse qui s'installe. La province Nord est placée en risque très élevé de feux de forêts, avec déjà des conséquences pour la biodiversité.
Developers of the PHP programming language said they had identified two critical vulnerabilities, and urged users to update their sites as soon as a fix was released.
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It’s been a month since the story of the Cornell Seven case became national news. Ruby Cramer documents what she describes as “an ever-expanding blast radius of online abuse, threats, and vigilantism which has touched virtually every person connected to the case, along with people who have no immediate connection to it at all.” Among those closest to the center is the accuser herself:
Jane Doe explained to the police that her phone number and address had been leaked on the internet, and that she’d been receiving harassing phone calls, including that evening. She had recorded one such call. In the recording, the man says, “I’m probably just gonna, like, pull up to your house and shoot. . . .” The caller speaks in a deep, throaty voice that at times sounds almost garbled. In response, Jane Doe says nothing. The man says, “I can hear you breathing.”
While officers were still at the family’s house, dispatch reported that the initial caller was back on the line, saying that he had an AR-15 assault rifle and was going to kill everyone at the house, then himself. About an hour later, police reported another call, this one saying that the house was on fire. In yet another phone call, a man stated that he had explosives and that the family would die—“either now, midnight, or tomorrow.” Jane Doe was receiving additional threats via text message and D.M. Her phone had hundreds of unread messages on it, but some of them she opened. “Typical white btich whore crying ‘rape,’ ” one of the messages read. “Hopefully someone does the world a favor and 🔫🔫🔫 you, nothing of value would be lost.” Officers advised her to keep her phone turned off. The next day, according to her attorney, she started taping pieces of paper over the windows at the house.
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